https://scholars.lib.ntu.edu.tw/handle/123456789/562486
標題: | Diagnosis of tuberculosis by an enzyme-linked immunospot assay for interferon-γ | 作者: | JANN-YUAN WANG Chou C.-H. LI-NA LEE Hsu H.-L. I-SHIOW JAN PO-REN HSUEH PAN-CHYR YANG KWEN-TAY LUH |
公開日期: | 2007 | 卷: | 13 | 期: | 4 | 起(迄)頁: | 553-558 | 來源出版物: | Emerging Infectious Diseases | 摘要: | We evaluated an enzyme-linked immunospot assay for interferon-γ (T SPOT-TB) for rapid diagnosis of active tuberculosis (TB) in a disease-endemic area. From January to June 2005, patients whose clinical symptoms and radiographic findings were compatible with TB were recruited, and a blood sample was obtained for T SPOT-TB assay within 7 days of microbiologic studies. Sixty-five patients were studied, including 39 (60%) with active TB. Thirty-five (53.8%) patients had underlying medical conditions. Thirty-seven patients had positive cultures for Mycobacterium tuberculosis, and 11 patients had positive cultures for non-tuberculous mycobacteria. The sensitivity, specificity, positive predictive value, and negative predictive value of the T SPOT-TB assay were 87.2%, 88.5%, 91.9%, and 82.1%, respectively. The accuracy of this test in diagnosing active TB is >80%, even in an area with a high incidence of non-tuberculous mycobacterial disease. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/562486 | ISSN: | 1080-6040 | DOI: | 10.3201/eid1304.051195 | SDG/關鍵字: | BCG vaccine; clarithromycin; ethambutol; gamma interferon; isoniazid; rifampicin; adolescent; adult; aged; article; bacterium culture; blood sampling; child; clinical feature; controlled study; diagnostic accuracy; enzyme linked immunospot assay; female; human; major clinical study; male; microbiological examination; morbidity; Mycobacterium tuberculosis; radiography; sensitivity and specificity; treatment response; tuberculosis |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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