https://scholars.lib.ntu.edu.tw/handle/123456789/562487
標題: | Disseminated tuberculosis: A 10-year experience in a medical center | 作者: | JANN-YUAN WANG PO-REN HSUEH Wang S.-K. I-SHIOW JAN LI-NA LEE Liaw Y.-S. PAN-CHYR YANG KWEN-TAY LUH |
公開日期: | 2007 | 卷: | 86 | 期: | 1 | 起(迄)頁: | 39-46 | 來源出版物: | Medicine | 摘要: | Disseminated tuberculosis remains a diagnostic challenge because the presentations are nonspecific. In the current retrospective study we describe the clinical characteristics and outcome of disseminated tuberculosis. From January 1995 to December 2004, patients with culture-confirmed tuberculosis who fulfilled the criteria for disseminated tuberculosis were selected and their medical records reviewed. Their clinical isolates were genotyped. Of the 3058 patients with culture-confirmed tuberculosis, 164 (5.4%) had disseminated disease; 14.0% of patients had acquired immunodeficiency syndrome. The most common radiographic finding was miliary lung lesions (47.0%); 31.1% of patients died at the end of the study. Poor prognostic factors included hypoalbuminemia, hyperbilirubinemia, renal insufficiency, and delayed antituberculosis treatment. Clinical findings suggestive of disseminated tuberculosis were miliary lung lesions, serum ferritin >1000 μg/L, infiltrative liver disease, and adjusted calcium >2.6 mmol/L. Simultaneously performing mycobacterial culture and histopathologic examination of bone marrow biopsy was more sensitive and faster than just performing mycobacterial blood culture in diagnosing disseminated tuberculosis. Of the 64 preserved Mycobacterium tuberculosis isolates, 47 (73.4%) were clustered and 27 (42.2%) were Beijing family. Since prognosis was worse in patients with delayed treatment, a high index of suspicion is required, especially in those with clinical findings suggestive of disseminated tuberculosis. ? 2007 Lippincott Williams & Wilkins, Inc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/562487 | ISSN: | 0025-7974 | DOI: | 10.1097/MD.0b013e318030b605 | SDG/關鍵字: | alanine aminotransferase; albumin; alkaline phosphatase; bilirubin; calcium; ethambutol; isoniazid; parathyroid hormone; phosphate; pyrazinamide; rifampicin; sodium; acquired immune deficiency syndrome; adult; article; bacterium culture; bacterium isolate; blood culture; bone marrow biopsy; calcium blood level; clinical feature; controlled study; diagnostic accuracy; early diagnosis; female; ferritin blood level; histopathology; human; hyperbilirubinemia; hypoalbuminemia; kidney failure; lung injury; lung tuberculosis; major clinical study; male; medical record; miliary tuberculosis; mortality; Mycobacterium tuberculosis; outcome assessment; patient selection; priority journal; prognosis; retrospective study; therapy delay; thorax radiography; tissue section; Adult; Aged; Aged, 80 and over; Female; HIV Infections; Humans; Male; Middle Aged; Retrospective Studies; Tuberculosis |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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