https://scholars.lib.ntu.edu.tw/handle/123456789/563268
標題: | Superoxide Dismutase 2 (SOD2) in Vascular Calcification: A Focus on Vascular Smooth Muscle Cells, Calcification Pathogenesis, and Therapeutic Strategies | 作者: | Tsai Y.-T. Yeh H.-Y. CHIA-TER CHAO CHIH-KANG CHIANG |
公開日期: | 2021 | 出版社: | Hindawi Limited | 卷: | 2021 | 來源出版物: | Oxidative Medicine and Cellular Longevity | 摘要: | Vascular calcification (VC) describes the pathophysiological phenotype of calcium apatite deposition within the vascular wall, leading to vascular stiffening and the loss of compliance. VC is never benign; the presence and severity of VC correlate closely with the risk of myocardial events and cardiovascular mortality in multiple at-risk populations such as patients with diabetes and chronic kidney disease. Mitochondrial dysfunction involving each of vascular wall constituents (endothelia and vascular smooth muscle cells (VSMCs)) aggravates various vascular pathologies, including atherosclerosis and VC. However, few studies address the pathogenic role of mitochondrial dysfunction during the course of VC, and mitochondrial reactive oxygen species (ROS) seem to lie in the pathophysiologic epicenter. Superoxide dismutase 2 (SOD2), through its preferential localization to the mitochondria, stands at the forefront against mitochondrial ROS in VSMCs and thus potentially modifies the probability of VC initiation or progression. In this review, we will provide a literature-based summary regarding the relationship between SOD2 and VC in the context of VSMCs. Apart from the conventional wisdom of attenuating mitochondrial ROS, SOD2 has been found to affect mitophagy and the formation of the autophagosome, suppress JAK/STAT as well as PI3K/Akt signaling, and retard vascular senescence, all of which underlie the beneficial influences on VC exerted by SOD2. More importantly, we outline the therapeutic potential of a novel SOD2-targeted strategy for the treatment of VC, including an ever-expanding list of pharmaceuticals and natural compounds. It is expected that VSMC SOD2 will become an important druggable target for treating VC in the future. ? 2021 You-Tien Tsai et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102359951&doi=10.1155%2f2021%2f6675548&partnerID=40&md5=f3498103897ce44b0411dd20bca93e4d https://scholars.lib.ntu.edu.tw/handle/123456789/563268 |
ISSN: | 1942-0900 | DOI: | 10.1155/2021/6675548 | SDG/關鍵字: | Biomineralization; Bone; Enzymes; Mitochondria; Phosphate minerals; Cardiovascular mortality; Chronic kidney disease; Mitochondrial dysfunction; Preferential localization; Superoxide dismutase 2; Therapeutic potentials; Vascular calcification; Vascular Smooth Muscle Cells; Muscle; cardiovascular agent; Janus kinase; manganese superoxide dismutase; phosphatidylinositol 3 kinase; protein kinase B; reactive oxygen metabolite; STAT protein; manganese superoxide dismutase; superoxide dismutase; autophagosome; blood vessel calcification; disorders of mitochondrial functions; drug targeting; human; JAK-STAT signaling; mitochondrion; mitophagy; nonhuman; pathogenesis; pathophysiology; Pi3K/Akt signaling; regulatory mechanism; Review; senescence; vascular smooth muscle cell; animal; biological model; blood vessel calcification; enzymology; metabolism; pathology; smooth muscle cell; vascular smooth muscle; Calcium; Cells; Deposition; Enzymes; Mitochondria; PI; Probability; Walls; Animals; Humans; Mitochondria; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Superoxide Dismutase; Vascular Calcification |
顯示於: | 毒理學研究所 |
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