https://scholars.lib.ntu.edu.tw/handle/123456789/563403
標題: | Plasma prohepcidin positively correlates with hematocrit in chronic hemodialysis patients | 作者: | Hsu S.-P. CHIH-KANG CHIANG Chien C.-T. KUAN-YU HUNG |
公開日期: | 2006 | 卷: | 24 | 期: | 3 | 起(迄)頁: | 311-316 | 來源出版物: | Blood Purification | 摘要: | Background/Aims: Experimental studies have demonstrated interleukin-6 and iron load induce expression of hepcidin (an iron regulatory peptide), whereas anemia and erythropoietin (EPO) suppress its expression. We are the first to explore the relationships of plasma prohepcidin (the pro-hormone of hepcidin) in patients undergoing chronic hemodialysis (HD). Methods: We enrolled 71 chronic HD patients. During the preceding 3 months before enrollment, they all had steady weekly levels of haematocrit (Hct) and fixed subcutaneous doses of recombinant human EPO. Plasma levels of prohepcidin, proinflammatory cytokines, and EPO were determined by ELISA kits. Results: Of the patients, prohepcidin levels correlated positively with Hct, and negatively with interleukin-6 and EPO. Examined by a multivariate lineal regression method, we found Hct was the only significant predictor of plasma prohepcidin level. However, prohepcidin had no significant correlation with iron profiles. Conclusion: Our findings suggest prohepcidin expression in chronic HD patients might be positively regulated by Hct. Copyright ? 2006 S. Karger AG. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33744498373&doi=10.1159%2f000091453&partnerID=40&md5=9ea23d0f3f2c9c9a4cbf200f9476d1d9 https://scholars.lib.ntu.edu.tw/handle/123456789/563403 |
ISSN: | 0253-5068 | DOI: | 10.1159/000091453 | SDG/關鍵字: | C reactive protein; hepcidin; interleukin 1beta; interleukin 6; iron; iron regulatory factor; prohepcidin; recombinant erythropoietin; tumor necrosis factor alpha; unclassified drug; adult; aged; anemia; article; correlation analysis; enzyme linked immunosorbent assay; erythropoiesis; female; hematocrit; hemodialysis; hormone determination; human; linear regression analysis; major clinical study; male; priority journal; protein expression; Adult; Aged; Aged, 80 and over; Antimicrobial Cationic Peptides; Chronic Disease; Cytokines; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Female; Hematocrit; Humans; Inflammation; Injections, Subcutaneous; Interleukin-6; Iron; Male; Middle Aged; Predictive Value of Tests; Protein Precursors; Recombinant Proteins; Renal Dialysis |
顯示於: | 毒理學研究所 |
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