|Title:||Quality control processes in allografting: A twenty-year retrospective review of a hospital-based bone bank in Taiwan||Authors:||Fu S.-H.
|Issue Date:||2017||Publisher:||Public Library of Science||Journal Volume:||12||Journal Issue:||10||Source:||PLoS ONE||Abstract:||
Musculoskeletal allografts are now commonly used. To decrease the potential risks of transmission of pathogenic bacteria, fungi, or viruses to the transplant recipients, certain issues regarding the management of patients who receive contaminated allografts need to be addressed. We aimed to clarify the incidence and extent of disease transmission from allografts by analyzing the allografting procedures performed in the bone bank of our hospital over the past 20 years. We retrospectively reviewed the data from our allograft registry center on 3979 allografts that were implanted in 3193 recipients throughout a period of two decades, from July 1991 to June 2011. The source of the allografts, results of all screening tests, dates of harvesting and implantation, and recipients of all allografts were checked. With the help of the Center for Infection Control of our hospital, a strict prospective, hospital-wide, on-site surveillance was conducted, and every patient with healthcare-associated infection was identified. Fisher’s exact test was used to compare the infection rate between recipients with sterile allografts and those with contaminated allografts. The overall discard and infection rates were, respectively, 23% and 1.3% in the first decade (1991–2001); and 18.4% and 1.25% in the second decade (2001–2011). The infection rate of contaminated allograft recipients was significantly higher than that of sterile allograft recipients (10% vs. 1.15%, P < 0.01) in the second decade. Both infection and discard rates of our bone bank are comparable with those of international bone banks. Strict allograft processing and adequate prophylactic use of antibiotics are critical to prevent infection and disease transmission in such cases. ? 2017 Fu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
|ISSN:||1932-6203||DOI:||10.1371/journal.pone.0184809||SDG/Keyword:||antibiotic agent; Article; bone allograft; bone bank; contaminated allograft; discard rate; disease severity; disease transmission; Fisher exact test; graft recipient; healthcare associated infection; hospital; human; implantation; incidence; infection rate; quality control; screening test; sterile allograft; surgical technique; Taiwan; adult; aged; allograft; female; hospital; male; middle aged; retrospective study; very elderly; young adult; Adult; Aged; Aged, 80 and over; Allografts; Bone Banks; Female; Hospitals; Humans; Male; Middle Aged; Quality Control; Retrospective Studies; Taiwan; Young Adult
|Appears in Collections:||醫學系|
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