https://scholars.lib.ntu.edu.tw/handle/123456789/563761
標題: | Thyroid carcinoma with bone metastases: A prognostic factor study | 作者: | Wu K. Hou S.-M. TIEN-SHANG HUANG RONG-SEN YANG |
關鍵字: | Bone; Carcinoma; Metastasis; Prognosis; Thyroid | 公開日期: | 2008 | 出版社: | Libertas Academica Ltd. | 卷: | 2 | 起(迄)頁: | 129-134 | 來源出版物: | Clinical Medicine: Oncology | 摘要: | Objective: Occult clinical presentations usually hinder the early detection and management of patients with bone metastases from thyroid carcinoma. We retrospectively investigated the clinical outcomes of such patients from 1993 to 2004 and analyzed the prognostic parameters.Design: The basic demographic data and manifestations of 44 patients who had thyroid carcinoma with bone metastases were reviewed. We studied the gender, age, locations of metastases, histological types, treatment methods, hypercalcemic episodes and results of treatments. We used Kaplan-Meier survival analysis and log-rank tests to access the statistical significance.Main outcome: The incidence of bone metastasis from thyroid carcinomas in this series was 5.0%. Twenty patients (45.4%) had follicular, 16 (36.3%) had papillary, 3 (6.8%) had anaplastic, 3 (6.8%) had medullary, and 2 (4.5%) had Hurthel cell carcinomas. Twelve patients had hypercalcemic episodes, ranging from 2.6 to 2.9 mmolL?1 (mean ± SD: 2.68 ± 0.15 mmolL?1). Survival time after bone metastases ranged from 2 months to 8 years (mean ± SD: 5.3 ± 1.3 years). The 5-year survival rate was 79.4% and the 10-year survival rate was 52.9%. Regarding the histological cancer type, patients with papillary and follicular cancers survived significantly longer than those with anaplastic and medullary cancers (p < 0.05). In addition, the patients presenting with hypercalcemia had the worst survival (p < 0.05).Conclusions: Thyroid carcinoma can present with bone metastases in its early stage. We found that both tumor type and hypercalcemia were significant prognostic factors for survival time. ? 2008 Libertas Academica Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880896734&doi=10.4137%2fcmo.s333&partnerID=40&md5=29d42a35f0d724676101f46644f482a1 https://scholars.lib.ntu.edu.tw/handle/123456789/563761 |
ISSN: | 1177-9314 | DOI: | 10.4137/cmo.s333 |
顯示於: | 醫學系 |
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