https://scholars.lib.ntu.edu.tw/handle/123456789/563782
標題: | Bone Mineral Density in Long-Term Chinese Heart Transplant Recipients: A Cross-Sectional Study | 作者: | NAI-KUAN CHOU Su I.C. Kuo H.L. Chen Y.H. RONG-SEN YANG SHOEI-SHEN WANG |
公開日期: | 2006 | 卷: | 38 | 期: | 7 | 起(迄)頁: | 2141-2144 | 來源出版物: | Transplantation Proceedings | 摘要: | Osteoporosis, which usually peaks during 6 to 12 months after transplantation, remains an important concern after heart transplantation. Immunosuppresants contribute to this phenomenon. Glucocorticoids are well documented to cause bone loss, but the role of cyclosporine (CsA) remains controversial, especially among long-term recipients on low doses of steroid. We herein report a cross-sectional study of bone mineral density (BMD) among long-term Chinese heart transplant recipients. We enrolled 41 patients of mean age 50.15 ± 13.58 years with a mean follow-up of 57.02 months. Lumbar spine and femoral neck BMD were measured by dual energy x-ray absorptiometry. Trough CsA levels (C0) and markers of mineral metabolism, including bone-specific alkaline phosphatase and urinary N-telopeptide, were determined by immunoassay. Sixty six percent of subjects showed bone loss at the femoral neck, significantly more than those in the lumbar spine. Those receiving a higher CsA dosage (<2.5 mg/kg/d) showed greater femoral neck BMD, but lower serum creatinine values. Our results demonstrated that bone loss remains long after transplantation, though bone markers are within normal limits. ? 2006 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33846081033&doi=10.1016%2fj.transproceed.2006.06.044&partnerID=40&md5=3a9d32b14e13d343b51ed6e82a297982 https://scholars.lib.ntu.edu.tw/handle/123456789/563782 |
ISSN: | 0041-1345 | DOI: | 10.1016/j.transproceed.2006.06.044 | SDG/關鍵字: | alkaline phosphatase; amino terminal telopeptide; biological marker; creatinine; cyclosporin A; glucocorticoid; immunosuppressive agent; prednisolone; steroid; thymocyte antibody; adult; article; bone density; cardiac graft rejection; Chinese; clinical article; creatinine blood level; dual energy X ray absorptiometry; female; femur neck; follow up; graft recipient; heart transplantation; human; immunoassay; lumbar spine; male; mineral metabolism; osteolysis; osteoporosis; priority journal; Adult; Aged; Body Size; Bone Density; Bone Diseases, Metabolic; Cross-Sectional Studies; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Prednisolone; Taiwan; Time Factors |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。