https://scholars.lib.ntu.edu.tw/handle/123456789/563955
標題: | Caffeic acid phenylethyl amide protects against the metabolic consequences in diabetes mellitus induced by diet and streptozocin | 作者: | Weng Y.-C. Chuang S.-T. Lin Y.-C. Chuang C.-F. Chi T.-C. Chiu H.-L. Kuo Y.-H. MING-JAI SU |
公開日期: | 2012 | 卷: | 2012 | 起(迄)頁: | 984780 | 來源出版物: | Evidence-based Complementary and Alternative Medicine | 摘要: | Caffeic acid phenyl ester is distributed wildly in nature and has antidiabetic and cardiovascular protective effects. However, rapid decomposition by esterase leads to its low bioavailability in vivo. In this study, chronic metabolic and cardiovascular effects of oral caffeic acid phenylethyl amide, whose structure is similar to caffeic acid phenyl ester and resveratrol, were investigated in ICR mice. We found that caffeic acid phenylethyl amide protected against diet or streptozocin-induced metabolic changes increased coronary flow and decreased infarct size after global ischemia-reperfusion in Langendorff perfused heart. Further study indicated that at least two pathways might be involved in such beneficial effects: the induction of the antioxidant protein MnSOD and the decrease of the proinflammatory cytokine TNF and NFB in the liver. However, the detailed mechanisms of caffeic acid phenylethyl amide need further studies. In summary, this study demonstrated the protective potential of chronic treatment of caffeic acid phenylethyl amide against the metabolic consequences in diabetes mellitus. Copyright ? 2012 Yi-Chun Weng et al. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/563955 | ISSN: | 1741427X | DOI: | 10.1155/2012/984780 | SDG/關鍵字: | caffeic acid phenethyl ester; glucose; immunoglobulin enhancer binding protein; manganese superoxide dismutase; metformin; streptozocin; tumor necrosis factor alpha; animal cell; animal experiment; animal model; animal tissue; article; controlled study; coronary artery blood flow; diabetes control; drug structure; glucose intolerance; heart infarction size; male; mouse; non insulin dependent diabetes mellitus; nonhuman; priority journal; reperfusion injury; streptozocin diabetes |
顯示於: | 藥理學科所 |
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