https://scholars.lib.ntu.edu.tw/handle/123456789/563967
標題: | Antihyperglycemic effect of a caffeamide derivative, KS370G, in normal and diabetic mice | 作者: | Weng Y.-C. Chiu H.-L. Lin Y.-C. Chi T.-C. Kuo Y.-H. MING-JAI SU |
公開日期: | 2010 | 卷: | 58 | 期: | 18 | 起(迄)頁: | 10033-10038 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | The antihyperglycemic actions of caffeamide derivatives, especially KS370G, in normal ICR, streptozotocin-induced diabetic (T1DM) and diet-induced diabetic (T2DM) mice were investigated in this study. Oral administration of the compound decreased the plasma glucose levels in both normal and diabetic mice, and appeared to be in a dose-dependent manner in normal and diet-induced type 2 diabetic mice. It was found that KS370G could stimulate the release of insulin in both normal and T2DM mice, and a dose of 1 mg per kg KS370G could significantly attenuate the increase of plasma glucose induced by an intraperitoneal glucose challenge test in normal and diabetic mice. Similar treatment with KS370G significantly increased glycogen content in both liver and skeletal muscle. Hence, the hypoglycemic effect of KS370G in normal and diabetic mice could be attributed to the stimulation of insulin release and the increase of glucose utilization. ? 2010 American Chemical Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/563967 | ISSN: | 218561 | DOI: | 10.1021/jf1024246 | SDG/關鍵字: | antihyperglycemia; Caffeamide; Diabetic mice; KS370G; T1DM; T2DM; Insulin; Nutrition; Glucose; antidiabetic agent; caffeic acid derivative; insulin; KS370G; animal; article; blood; chemistry; dose response; glucose blood level; Institute for Cancer Research mouse; insulin dependent diabetes mellitus; male; metabolism; mouse; non insulin dependent diabetes mellitus; synthesis; Animals; Blood Glucose; Caffeic Acids; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred ICR; Mus |
顯示於: | 藥理學科所 |
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