https://scholars.lib.ntu.edu.tw/handle/123456789/563986
標題: | Serotonin enhances β-endorphin secretion to lower plasma glucose in streptozotocin-induced diabetic rats | 作者: | Chi T.-C. Ho Y.-J. Chen W.-P. Chi T.-L. SHOEI-SHENG LEE Cheng J.-T. MING-JAI SU |
公開日期: | 2007 | 卷: | 80 | 期: | 20 | 起(迄)頁: | 1832-1838 | 來源出版物: | Life Sciences | 摘要: | Although serotonin, serotonin uptake inhibitors and serotonin precursors (including tryptophan or 5-hydroxytryptophan) are known to have hypoglycemic action in rodents or human, it is not clear whether serotonin has hypoglycemic effect in streptozotocin-induced diabetic rats (STZ-diabetic rats). The aim of this study was to investigate the action of serotonin in regulating the plasma glucose STZ-diabetic rats. Plasma glucose, insulin, β-endorphin and adrenaline were assessed after intraperitoneal administration of serotonin. Serotonin produced hypoglycemic effects without altering plasma insulin and adrenaline levels but increasing β-endorphin level in STZ-diabetic rats. The glycogen content in soleus muscle was increased at 90?min after application of serotonin (0.3?mg/kg) in STZ-diabetic rats. Dihydroergotamine (non-selective 5-HT receptor blocker) and pimozide (5-HT7 receptor blocker) abolished the hypoglycemic effect of serotonin in STZ-diabetic rats. Serotonin-induced hypoglycemic effect in association with the increase of β-endorphin release was abolished in bilaterally adrenalectomized STZ-diabetic rats. In isolated adrenal gland of STZ-diabetic rats, the increase of β-endorphin secretion in response to serotonin was reduced by either dihydroergotamine or pimozide. Pretreatment with naloxone (1.0?mg/kg, i.p.) prevented serotonin-induced plasma glucose lowering effect in STZ-diabetic rats. The results demonstrated that serotonin may activate 5-HT7 receptor on rat adrenal gland to enhance of β-endorphin secretion, which then stimulates the opioid receptor to increase peripheral glucose utilization, resulting in decreased plasma glucose levels in STZ-diabetic rats. ? 2007 Elsevier Inc. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/563986 | ISSN: | 243205 | DOI: | 10.1016/j.lfs.2007.02.016 | SDG/關鍵字: | 5 hydroxytryptophan; adrenalin; beta endorphin; dihydroergotamine; glucose; glycogen; insulin; naloxone; opiate receptor; pimozide; serotonin; serotonin 7 receptor; serotonin antagonist; serotonin uptake inhibitor; streptozocin; tryptophan; adrenal gland; adrenalin blood level; animal experiment; animal model; animal tissue; article; controlled study; glucose blood level; glucose utilization; hormone release; hypoglycemia; insulin blood level; male; nonhuman; rat; soleus muscle; streptozocin diabetes; Adrenal Glands; Animals; beta-Endorphin; Blood Glucose; Diabetes Mellitus, Experimental; Epinephrine; Glycogen; Hypoglycemia; Hypoglycemic Agents; Male; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Streptozocin; Rattus; Rodentia |
顯示於: | 藥理學科所 |
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