https://scholars.lib.ntu.edu.tw/handle/123456789/563995
標題: | Arterial stiffening and cardiac hypertrophy in a new rat model of type 2 diabetes | 作者: | KUO-CHU CHANG Tseng C.-D. Chou T.-F. Cho Y.-L. Chi T.-C. MING-JAI SU Tseng Y.-Z. |
公開日期: | 2006 | 卷: | 36 | 期: | 1 | 起(迄)頁: | 1月7日 | 來源出版物: | European Journal of Clinical Investigation | 摘要: | Background: We determined the effects of NIDDM on haemodynamic parameters describing arterial wall elasticity and cardiac hypertrophy in rats administered streptozotocin (STZ) and nicotinamide (NA), using the aortic impedance analysis. Methods: Male Wistar rats at 2 months were administered intraperitoneally 180 mg kg-1 of NA, 30 min before an intravenous injection of 50 mg kg-1 STZ, to induce type 2 diabetes. The STZ-NA rats were divided into two groups, 4 weeks and 8 weeks after induction of diabetes, and compared with untreated age-matched controls. Pulsatile aortic pressure and flow signals were measured by a high-fidelity pressure sensor and electromagnetic flow probe, respectively, and were then subjected to Fourier transformation for the analysis of aortic input impedance. Results: In each diabetic group, the experimental syndrome was characterized by a moderate and stable hyperglycaemia and a relative deficiency of insulin secretion. However, the 8-week but not the 4-week STZ-NA diabetic rats showed a decrease in cardiac output in the absence of any significant changes in mean aortic pressure, having increased total peripheral resistance. The diabetic syndrome at 8 weeks also contributed to an increase in aortic characteristic impedance, from 1.49 ± 0.33 (mean ± SD) to 1.95 ± 0.28 mmHg s mL-1 (P < 0.05), suggesting a detriment to the aortic distensibility in NIDDM. Meanwhile, the STZ-NA diabetic animals after 8 weeks had an increased wave reflection factor (0.46 ± 0.09 vs. 0.61 ± 0.13, P < 0.05) and decreased wave transit time (25.8 ± 3.8 vs. 20.6 ± 2.8 ms, P < 0.05). Ratio of the left ventricular weight to body weight was also enhanced in the 8-week STZ-NA diabetic rats. Conclusion: The heavy intensity with early return of the pulse wave reflection may augment systolic load of the left ventricle coupled to the arterial system, leading to cardiac hypertrophy in the rats at 8 weeks after following STZ and NA administration. ? 2006 Blackwell Publishing Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/563995 | ISSN: | 142972 | DOI: | 10.1111/j.1365-2362.2006.01588.x | SDG/關鍵字: | insulin; nicotinamide; streptozocin; animal experiment; animal model; animal tissue; aorta flow; aorta pressure; artery compliance; artery intima proliferation; artery wall; article; atherosclerosis; body weight; controlled study; diabetogenesis; Fourier transformation; heart left ventricle hypertrophy; heart output; heart output measurement; heart ventricle hypertrophy; heart weight; hyperglycemia; impedance cardiography; insulin release; male; non insulin dependent diabetes mellitus; nonhuman; priority journal; pulse wave; rat; species comparison; streptozocin diabetes; surface charge; vascular resistance; Animals; Aorta; Cardiomegaly; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Elasticity; Electrophoresis, Polyacrylamide Gel; Hemodynamic Processes; Male; Pulsatile Flow; Rats; Rats, Wistar; Vascular Resistance |
顯示於: | 藥理學科所 |
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