https://scholars.lib.ntu.edu.tw/handle/123456789/564122
標題: | Antirestenosis effect of butein in the neointima formation progression | 作者: | Chen Y.-N. TUR-FU HUANG Chang C.-H. Hsu C.-C. Lin K.-T. Wang S.-W. Peng H.-C. Chung C.-H. |
公開日期: | 2012 | 卷: | 60 | 期: | 27 | 起(迄)頁: | 6832-6838 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | The development of restenosis involves migration and hyperproliferation of vascular smooth muscle cells (VSMCs). Platelet-derived growth factor (PDGF) is one of the major factors. Butein modulates inflammatory pathways and affects the proliferation and invasion of the tumor. We investigated the hypothesis that butein might prevent the restenosis process via a similar pathway. Our results demonstrated that butein inhibited PDGF-induced VSMC proliferation and migration as determined by BrdU proliferation and two-dimensional migration scratch assay. Butein also concentration-dependently repressed PDGF-induced phosphorylation of PDGF-receptor β, mitogen-activated protein kinases, phosphoinositide 3-kinase/Akt, and phopholipase Cγ/c-Src in VSMCs. In addition, in vivo results showed that butein attenuated neointima formation in balloon-injured rat carotid arteries. These results indicate that butein may inhibit PDGF-induced VSMC proliferation and migration, resulting in attenuation of neointima formation after percutaneous transluminal coronary angioplasty. Our study demonstrates for the first time that systemic administration of butein is able to reduce neointima formation after vascular injury. ? 2012 American Chemical Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/564122 | ISSN: | 218561 | DOI: | 10.1021/jf300771x | SDG/關鍵字: | butein; migration; PDGF; Restenosis; Smooth muscle cells; Phosphorylation; Diseases; butein; chalcone derivative; mitogen activated protein kinase; platelet derived growth factor; protein kinase B; animal; article; cell culture; cell motion; cell proliferation; cytology; drug effect; genetics; human; male; metabolism; neointima; pathophysiology; phosphorylation; rat; restenosis; signal transduction; smooth muscle fiber; Wistar rat; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Chalcones; Coronary Restenosis; Humans; Male; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; Neointima; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Rattus |
顯示於: | 藥理學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。