https://scholars.lib.ntu.edu.tw/handle/123456789/564805
標題: | Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair | 作者: | Hsu J.-L. Leong P.-K. Ho Y.-F. LIH-CHING HSU Lu P.-H. Chen C.-S. JIH-HWA GUH |
公開日期: | 2012 | 卷: | 319 | 期: | 2 | 起(迄)頁: | 214-222 | 來源出版物: | Cancer Letters | 摘要: | The knockdown of Pim-1 or inhibition of Pim-1 activity significantly increased γ-H2A.X expression. The effect was correlated to apoptosis and was attributed to the inhibition of nonhomologous DNA-end-joining (NHEJ) repair activity supported by the following observations: (1) inhibition of ATM and DNA-PKcs activities, (2) down-regulation of Ku expression and nuclear localization and (3) decrease of DNA end-binding of both Ku70 and Ku80. The data suggest that Pim-1 plays a crucial role in the regulation of NHEJ repair. In the absence of Pim-1, the ability of DNA repair significantly decreases when exposed to paclitaxel, leading to severe DNA damage and apoptosis. ? 2012 Elsevier Ireland Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862793343&doi=10.1016%2fj.canlet.2012.01.004&partnerID=40&md5=769176657b0879e907fc3fe18dba786e https://scholars.lib.ntu.edu.tw/handle/123456789/564805 |
ISSN: | 3043835 | DOI: | 10.1016/j.canlet.2012.01.004 | SDG/關鍵字: | ATM protein; histone H2AX; Ku antigen; Ku80 antigen; paclitaxel; protein kinase Pim 1; small interfering RNA; unclassified drug; apoptosis; article; cell nucleus; controlled study; correlation analysis; DNA end joining repair; down regulation; gene silencing; human; human cell; male; priority journal; prostate cancer; protein expression; protein function; protein localization; Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA End-Joining Repair; DNA Helicases; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Histones; Humans; Male; Microtubules; Paclitaxel; Prostatic Neoplasms; Proto-Oncogene Proteins c-pim-1 |
顯示於: | 藥學系 |
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