https://scholars.lib.ntu.edu.tw/handle/123456789/564809
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen C.-N. | en_US |
dc.contributor.author | Hsiao C.-J. | en_US |
dc.contributor.author | SHOEI-SHENG LEE | en_US |
dc.contributor.author | JIH-HWA GUH | en_US |
dc.contributor.author | Chiang P.-C. | en_US |
dc.contributor.author | Huang C.-C. | en_US |
dc.contributor.author | Huang W.-J. | en_US |
dc.date.accessioned | 2021-06-02T05:43:46Z | - |
dc.date.available | 2021-06-02T05:43:46Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 14786419 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863064594&doi=10.1080%2f14786419.2010.535146&partnerID=40&md5=c424143a51a0a677b1f0b2ece7f44b41 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/564809 | - |
dc.description.abstract | Our previous studies demonstrated that eight prenylated flavanones (1-8), isolated from Taiwanese propolis, were capable of a broad spectrum of biological activities. Among them, nymphaeol A (3), nymphaeol B (4) and nymphaeol C (7), abundant in Taiwanese propolis, exhibited cytotoxicity against cancer cell lines. It therefore seemed interesting to improve their activity via a semi-synthetic strategy. In this study, 12 novel prenylated flavanones were synthesised in our laboratory and their activities were assessed for two human prostate cancer cell lines, PC-3 and DU-145, and a human hepatoma cell line, Hep-3B. Of these compounds, 10c, 11 and 12 showed more potent cytotoxicity against the PC-3 cell line than 5-Fu. Using cytometric analysis followed by double staining with annexin V-FITC and propidium iodide, it was observed that these compounds induced apoptosis as well. This suggests that prenylated flavanones 10c, 11 and 12 may have anticancer potential for further development. ? 2012 Copyright Taylor and Francis Group, LLC. | - |
dc.relation.ispartof | Natural Product Research | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 2',6 di(2 carboxylethyl) 3',4',5,7 tetramethoxyflavanone; 2',6 di(2 oxo ethyl) 3',4',5,7 tetramethoxyflavanone; 3 (3 hydroxy 3 methylbutyl) 2' (7 hydroxy 3,7 dimethyloct 3 enyl) 6 hydroxy 3',4',2,4 tetramethoxychalcone; 3',4',7 o trimethylnymphaeol c; 6 (3 hydroxy 3 methylbutyl) 2' (7 hydroxy 3,7 dimethyloctyl) 3',4',5,7 tetramethoxyflavanon; annexin; antineoplastic agent; flavone derivative; nymphaeol a; nymphaeol b; nymphaeol c; propidium iodide; propolis; unclassified drug; antineoplastic activity; apoptosis; article; cancer cell; chemical modification; controlled study; cytometry; human; human cell; liver cell carcinoma; prostate cancer; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Discovery; Flavanones; Flow Cytometry; Humans; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Prenylation; Propolis; Prostatic Neoplasms; Taiwan | - |
dc.title | Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1080/14786419.2010.535146 | - |
dc.identifier.pmid | 21790499 | - |
dc.identifier.scopus | 2-s2.0-84863064594 | - |
dc.relation.pages | 116-124 | - |
dc.relation.journalvolume | 26 | - |
dc.relation.journalissue | 2 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | School of Pharmacy | - |
crisitem.author.orcid | 0000-0002-6628-2448 | - |
crisitem.author.orcid | 0000-0002-6738-6054 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 藥學系 |
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