https://scholars.lib.ntu.edu.tw/handle/123456789/564825
標題: | Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo | 作者: | Tsai A.-C. Pan S.-L. Liao C.-H. JIH-HWA GUH Wang S.-W. Sun H.-L. Liu Y.-N. Chen C.-C. Shen C.-C. Chang Y.-L. Teng C.-M. |
公開日期: | 2010 | 卷: | 292 | 期: | 2 | 起(迄)頁: | 163-170 | 來源出版物: | Cancer Letters | 摘要: | Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization. In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin. Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs. These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy. ? 2009 Elsevier Ireland Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77951913859&doi=10.1016%2fj.canlet.2009.11.020&partnerID=40&md5=7d5576da62a1e6cfd3ec1886b4d142bf https://scholars.lib.ntu.edu.tw/handle/123456789/564825 |
ISSN: | 3043835 | DOI: | 10.1016/j.canlet.2009.11.020 | SDG/關鍵字: | antineoplastic agent; basic fibroblast growth factor; mitogen activated protein kinase 1; mitogen activated protein kinase 3; moscatilin; protein kinase B; unclassified drug; vasculotropin; benzyl derivative; dendrophenol; fibroblast growth factor 2; plant extract; vasculotropin A; animal experiment; animal model; antiangiogenic activity; antineoplastic activity; article; cancer cell culture; cancer inhibition; cell migration; cell proliferation; controlled study; Dendrobium; Dendrobium loddigesii; drug mechanism; drug targeting; endothelium cell; enzyme activation; human; human cell; human umbilical vein endothelium cell; in vitro study; in vivo study; male; mouse; nonhuman; priority journal; signal transduction; tumor vascularization; Western blotting; animal; C57BL mouse; cell division; cell line; chemistry; Dendrobium; drug effect; neoplasm; neovascularization (pathology); nude mouse; pathology; physiology; vascularization; Animals; Benzyl Compounds; Blotting, Western; Cell Division; Cell Line; Dendrobium; Fibroblast Growth Factor 2; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasms; Neovascularization, Pathologic; Plant Extracts; Vascular Endothelial Growth Factor A |
顯示於: | 藥學系 |
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