https://scholars.lib.ntu.edu.tw/handle/123456789/564844
標題: | CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression | 作者: | Wang S.-W. Pan S.-L. Peng C.-Y. Huang D.-Y. Tsai A.-C. Chang Y.-L. JIH-HWA GUH Kuo S.-C. Lee K.-H. Teng C.-M. |
公開日期: | 2007 | 卷: | 257 | 期: | 1 | 起(迄)頁: | 87-96 | 來源出版物: | Cancer Letters | 摘要: | Clinical observations suggest that hepatocyte growth factor (HGF) can promote invasion and metastasis in hepatocellular carcinoma. In this study, we found that HGF-stimulated invasion of SK-Hep-1 cells, together with increased expression of matrix metalloproteinase (MMP)-9. CHM-1 was identified from 2-phenyl-4-quinolone derivatives to potently inhibit HGF-induced cell invasion, proteolytic activity, and expression of MMP-9. CHM-1 significantly inhibited tyrosine autophosphorylation of c-Met induced by HGF. CHM-1 also suppressed HGF-induced Akt phosphorylation, and NF-κB activation, the downstream regulators of HGF/c-Met signaling, resulting in the inhibition of MMP-9. Thus, we suggest that CHM-1 is a potential therapeutic agent against tumor invasion. ? 2007 Elsevier Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34848825642&doi=10.1016%2fj.canlet.2007.07.002&partnerID=40&md5=762805ead0000f94229e6c7508fe7136 https://scholars.lib.ntu.edu.tw/handle/123456789/564844 |
ISSN: | 3043835 | DOI: | 10.1016/j.canlet.2007.07.002 | SDG/關鍵字: | 2 phenyl 4 quinolone derivative; 2' fluoro 6,7 methylenedioxy 2 phenyl 4 quinolone derivative; gelatinase B; immunoglobulin enhancer binding protein; protein kinase B; quinolone derivative; scatter factor; scatter factor receptor; tyrosine; unclassified drug; article; cancer cell; cancer invasion; cell invasion; cell line; controlled study; drug mechanism; drug structure; drug targeting; human; human cell; liver cell carcinoma; metastasis; priority journal; protein degradation; protein expression; protein phosphorylation; protein synthesis inhibition; signal transduction; Antineoplastic Agents; Cell Line, Tumor; Dioxoles; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; I-kappa B Kinase; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Models, Biological; Models, Chemical; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Phosphorylation; Quinolones |
顯示於: | 藥學系 |
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