https://scholars.lib.ntu.edu.tw/handle/123456789/564874
標題: | New Cytotoxic Clerodane Diterpenoids from the Leaves and Twigs of Casearia membranacea | 作者: | Shen Y.-C. Wang C.-H. Cheng Y.-B. Wang L.-T. JIH-HWA GUH Chien C.-T. Khalil A.T. |
公開日期: | 2004 | 卷: | 67 | 期: | 3 | 起(迄)頁: | 316-321 | 來源出版物: | Journal of Natural Products | 摘要: | Bioassay-guided fractionation of an EtOAc-soluble extract of Casearia membranacea has resulted in the isolation of six new clerodane diterpenes, caseamembrins A-F (1-6), and a known compound, rel-(2S,5R,6R,8S,9S,10R,18S,19R)-diacetoxy-18, 19-epoxy-6-hydroxy-2-(2-methylbutanoyloxy)cleroda-3,13(16),14-triene (7). The structures of 1-6 were established on the basis of extensive 1D and 2D NMR spectroscopic analysis. In addition, the new derivatives, 8 and 9, were prepared by acylation of 7 and 3, respectively. The isolated diterpenoids and their derivatives were tested against human prostate (PC-3) and hepatoma (Hep3B) cancer cells. Compounds 1, 3-5, and 7 exhibited cytotoxicity against both tumor cells, with IC50 values below 3 μM, while compounds 2, 6, 8, and 9 were less effective. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-1642547025&doi=10.1021%2fnp0303658&partnerID=40&md5=609b658d7cc7e1a15e401bbaf38341c7 https://scholars.lib.ntu.edu.tw/handle/123456789/564874 |
ISSN: | 1633864 | DOI: | 10.1021/np0303658 | SDG/關鍵字: | caseamembrin a; caseamembrin b; caseamembrin c; caseamembrin d; caseamembrin e; caseamembrin f; Casearia membranacea extract; clerodane derivative; cytotoxic agent; diacetoxy 18,19 epoxy 6 hydroxy 2 (2 methylbutanoyloxy)cleroda 3,13(16),14 triene; diterpenoid; paclitaxel; unclassified drug; article; Casearia; Casearia membranacea; controlled study; cytotoxicity; drug efficacy; drug isolation; drug structure; drug synthesis; human; human cell; IC 50; liver cell carcinoma; plant leaf; prostate cancer; structure analysis; Acetylation; Antineoplastic Agents, Phytogenic; Casearia; Diterpenes, Clerodane; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves; Plants, Medicinal; Taiwan; Tumor Cells, Cultured; Casearia |
顯示於: | 藥學系 |
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