https://scholars.lib.ntu.edu.tw/handle/123456789/565086
標題: | Inhibitor of DNA-binding protein 4 suppresses cancer metastasis through the regulation of epithelial mesenchymal transition in lung adenocarcinoma | 作者: | Wang C.-C. Hsu Y.-L. Chang C.-J. Wang C.-J. Hsiao T.-H. SZU-HUA PAN |
關鍵字: | EMT; Id4; Lung cancer; MET; Metastasis | 公開日期: | 2019 | 出版社: | MDPI AG | 卷: | 11 | 期: | 12 | 來源出版物: | Cancers | 摘要: | Metastasis is a predominant cause of cancer death and the major challenge in treating lung adenocarcinoma (LADC).Therefore, exploring new metastasis-related genes and their action mechanisms may provide new insights for developing a new combative approach to treat lung cancer.Previously, our research team discovered that the expression of the inhibitor of DNA binding 4 (Id4) was inversely related to cell invasiveness in LADC cells by cDNA microarray screening.However, the functional role of Id4 and its mechanism of action in lung cancer metastasis remain unclear.In this study, we report that the expression of Id4 could attenuate cell migration and invasion in vitro and cancer metastasis in vivo.Detailed analyses indicated that Id4 could promote E-cadherin expression through the binding of Slug, cause the occurrence of mesenchymal-epithelial transition (MET), and inhibit cancer metastasis.Moreover, the examination of the gene expression database (GSE31210) also revealed that high-level expression of Id4/E-cadherin and low-level expression of Slug were associated with a better clinical outcome in LADC patients.In summary, Id4 may act as a metastatic suppressor, which could not only be used as an independent predictor but also serve as a potential therapeutic for LADC treatment. ? 2019 by the authors.Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076756582&doi=10.3390%2fcancers11122021&partnerID=40&md5=e2ad6c3ec837264823d4a6cac51b2d9f https://scholars.lib.ntu.edu.tw/handle/123456789/565086 |
ISSN: | 2072-6694 | DOI: | 10.3390/cancers11122021 | SDG/關鍵字: | complementary DNA; DNA binding protein; inhibitor of DNA binding 4; transcription factor Slug; unclassified drug; uvomorulin; animal experiment; animal model; animal tissue; apoptosis; Article; cell invasion; cell migration; controlled study; DNA microarray; enzyme inhibition; enzyme regulation; enzyme repression; epithelial mesenchymal transition; human; human cell; in vitro study; in vivo study; lung adenocarcinoma; male; metastasis potential; mouse; nonhuman; overall survival; protein binding; protein expression; protein function; protein protein interaction; recurrence free survival |
顯示於: | 基因體暨蛋白體醫學研究所 |
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