https://scholars.lib.ntu.edu.tw/handle/123456789/565387
標題: | New Perspectives on Genetic Prediction for Pediatric Metabolic Associated Fatty Liver Disease | 作者: | Lin Y.-C. Wu C.-C. YEN-HSUAN NI |
關鍵字: | children; fatty liver; genetics; obesity; pediatric; precision medicine; sequence variation | 公開日期: | 2020 | 出版社: | Frontiers Media S.A. | 卷: | 8 | 起(迄)頁: | 603654 | 來源出版物: | Frontiers in Pediatrics | 摘要: | Non-alcoholic or recently re-defined metabolic associated fatty liver disease (MAFLD), a spectrum of progressive hepatic disease, has become a public health issue in obese children and adolescents. MAFLD is a complex metabolic disease strongly associated with obesity and insulin resistance. It is not known why not every obese subject will develop MAFLD. Different ethnic/racial groups display differences in MAFLD prevalence, indicating genetic factor plays a role. In the past two decades, sequence variations in genetic loci, including PNPLA3, TM6SF2, GCKR, MBOAT7, HSD17B13, etc. have been shown to confer susceptibility to MAFLD in children and adults. This review article provides an updated viewpoint of genetic predictors related to pediatric MAFLD. We discuss whether these susceptible genes can be clinically used for risk stratification and personalized care. Understanding human genetics and molecular mechanisms can give important information not only for prediction of risk but also on how to design drugs. In view of current epidemic of MAFLD worldwide, it is necessary to identify which children with MAFLD progress rapidly and need earlier intervention. In the future, a comprehensive analysis of individualized genetic and environmental factors may help assess the risk of children with MAFLD and personalize their treatment. ? Copyright ? 2020 Lin, Wu and Ni. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098076138&doi=10.3389%2ffped.2020.603654&partnerID=40&md5=7b18edb5085541980ca005604f177702 https://scholars.lib.ntu.edu.tw/handle/123456789/565387 |
ISSN: | 2296-2360 | DOI: | 10.3389/fped.2020.603654 | SDG/關鍵字: | acyltransferase; beta Klotho protein; cannabinoid receptor; cannabinoid receptor type 2; farnesyl diphosphate farnesyltransferase 1; G protein coupled receptor 120; glucokinase; glucokinase regulator protein; glucuronosyltransferase 1A1; heme oxygenase 1; hydroxysteroid 17 beta dehydrogenase 13; hydroxysteroid dehydrogenase; immunity related gtpase family m protein; insulin; insulin receptor substrate 1; Klotho protein; kruppel like factor 6; lipid; lipin 1; M protein; membrane bound o acyltransferase domain containing protein 7; membrane protein; microsomal triglyceride transfer protein; patatin like phospholipase domain containing 3; peroxisome proliferator activated receptor gamma coactivator 1alpha; phospholipase; squalene synthase; transmembrane 6 superfamily member 2; unclassified drug; adolescent; adult; child; environmental factor; fatty liver; fibrogenesis; genetic association; genetic variability; genetic variation; heredity; heritability; human; inflammation; insulin resistance; lipid liver level; lipid metabolism; metabolic associated fatty liver disease; nonhuman; oxidative stress; pathogenesis; prediction; Review |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。