|Title:||Fecal calprotectin correlated with endoscopic remission for Asian inflammatory bowel disease patients||Authors:||Lin W.-C.
Taiwan Society of Inflammatory Bowel Disease Multicenter Study
|Issue Date:||2015||Publisher:||Baishideng Publishing Group Co||Journal Volume:||21||Journal Issue:||48||Start page/Pages:||13566-13573||Source:||World Journal of Gastroenterology||Abstract:||
AIM: To evaluate the correlation between fecal calprotectin (fC), C-reactive protein (CRP), and endoscopic disease score in Asian inflammatory bowel disease (IBD) patients. METHODS: Stool samples were collected and assessed for calprotectin levels by Quantum Blue Calprotectin High Range Rapid test. Crohn's disease endoscopic index of severity (CDEIS) and ulcerative colitis endoscopic index of severity (UCEIS) were used for endoscopic lesion scoring. RESULTS: A total of 88 IBD patients [36 patients with Crohn's disease (CD) and 52 with ulcerative colitis (UC)] were enrolled. For CD patients, fC correlated with CDEIS (r = 0.465, p = 0.005) and CRP (r = 0.528, p = 0.001). fC levels in UC patients correlated with UCEIS (r = 0.696, p < 0.0001) and CRP (r = 0.529, p = 0.0005). Calprotectin could predict endoscopic remission (CDEIS < 6) with 50% sensitivity and 100% specificity (AUC: 0.74) in CD patients when using 918 μg/g as the cutoff. When using 191 μg/g as the cut-off in UC patients, calprotectin could be used for predicting endoscopic remission (UCEIS < 3) with 88% sensitivity and 75% specificity (AUC: 0.87). CONCLUSION: fC correlated with both CDEIS and UCEIS. fC could be used as a predictor of endoscopic remission for Asian IBD patients. ? 2015 Baishideng Publishing Group Inc. All rights reserved.
|ISSN:||1007-9327||DOI:||10.3748/wjg.v21.i48.13566||SDG/Keyword:||biological marker; C reactive protein; calgranulin; biological marker; C reactive protein; calgranulin; adolescent; adult; aged; area under the curve; Article; Asian; colonoscopy; correlation coefficient; Crohn disease; Crohn's Disease Endoscopic Index of Severity; digestive system disease assessment; feces analysis; feces level; female; groups by age; human; ileocolonoscopy; major clinical study; male; multicenter study; proctitis; prospective study; remission; sensitivity and specificity; ulcerative colitis; Ulcerative Colitis Endoscopic Index of Severity; Asian continental ancestry group; chemistry; Colitis, Ulcerative; colon; Crohn disease; drug effects; ethnology; feces; metabolism; middle aged; pathology; predictive value; severity of illness index; Taiwan; treatment outcome; young adult; Adolescent; Adult; Aged; Asian Continental Ancestry Group; Biomarkers; C-Reactive Protein; Colitis, Ulcerative; Colon; Colonoscopy; Crohn Disease; Feces; Female; Humans; Leukocyte L1 Antigen Complex; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Remission Induction; Severity of Illness Index; Taiwan; Treatment Outcome; Young Adult
|Appears in Collections:||醫學系|
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