https://scholars.lib.ntu.edu.tw/handle/123456789/566390
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chi H. | en_US |
dc.contributor.author | Chiu N.-C. | en_US |
dc.contributor.author | Huang F.-Y. | en_US |
dc.contributor.author | Hsu C.-H. | en_US |
dc.contributor.author | Lee K.-S. | en_US |
dc.contributor.author | LI-MIN HUANG | en_US |
dc.contributor.author | Hsieh Y.-C. | en_US |
dc.date.accessioned | 2021-06-24T07:16:16Z | - |
dc.date.available | 2021-06-24T07:16:16Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009499723&doi=10.1016%2fj.jmii.2016.08.002&partnerID=40&md5=b01537c5eb484b2b8ede4efc5e08119f | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/566390 | - |
dc.description.abstract | Background: Streptococcus pneumoniae serotype 19A ST320, a highly multiresistant and virulent clone, has emerged as a common pathogen causing acute otitis media (AOM) in children. Methods: Patients aged 0–18 years with AOM who presented at Mackay Memorial Hospital, Taipei, Taiwan were prospectively enrolled between December 1, 2009, and November 30, 2012. For each patient, a specimen of middle-ear fluid was obtained and cultured. S. pneumoniae isolates were tested by serotyping, antibiotic-resistance profiling, and multilocus sequence typing. Demographic characteristics and clinical history of patients with pneumococcal AOM were recorded. Results: Pneumococcal AOM was observed in 108 (24.8%) of 436 episodes. One hundred and four isolates of S. pneumoniae were available for study. The most common serotypes were 19A (67 isolates, 64.4%), followed by 19F (16 isolates, 15.4%), and 3 (7 isolates, 6.7%). Among the 85 sequence-typed isolates, Serotype 19A ST320 (50, 58.8%) was the most frequent. Children with AOM caused by Serotype 19A ST320 were younger (33.9 ± 21.4 months vs. 46.7 ± 35.9 months, p = 0.04) and had a higher rate of spontaneous rupture of the tympanic membrane (64.0% vs. 40%, p = 0.05) than those caused by isolates of other sequence types. Serotype 19A ST320 caused 90% of AOM episodes in children aged ? 12 months and had had higher resistance rates to penicillin according to meningeal breakpoints (p = 0.011), amoxicillin (p < 0.001) and trimethoprim/sulfamethoxazol (p < 0.001). Conclusions: It is better to use pneumococcal conjugate vaccine effective against Serotype 19A in early infancy to prevent the first and subsequent episodes of AOM in children in Taiwan. ? 2017 | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.ispartof | Journal of Microbiology, Immunology and Infection | - |
dc.subject | acute otitis media; Serotype 19A; Streptococcus pneumoniae | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amoxicillin; amoxicillin plus clavulanic acid; cefixime; cefotaxime; ceftriaxone; chloramphenicol; cotrimoxazole; erythromycin; levofloxacin; penicillin derivative; Pneumococcus vaccine; tetracycline; vancomycin; amoxicillin; antiinfective agent; penicillin derivative; sulfamethoxazole; trimethoprim; vaccine; acute otitis media; adolescent; adult; antibiotic resistance; Article; bacterial strain; bacterium culture; bacterium isolate; child; clinical article; clinical feature; clone; drug efficacy; eardrum perforation; epidemiological data; female; Haemophilus influenzae; human; infant; male; middle ear; Moraxella catarrhalis; multilocus sequence typing; newborn; nonhuman; prospective study; serotyping; Streptococcus pneumoniae; Streptococcus pyogenes; Taiwan; classification; genetics; immunology; isolation and purification; microbial sensitivity test; microbiology; middle aged; otitis media; pathogenicity; pneumococcal infection; preschool child; prevalence; serotype; Streptococcus pneumoniae; young adult; Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Child; Child, Preschool; Drug Resistance, Bacterial; Female; Humans; Infant; Infant, Newborn; Male; Microbial Sensitivity Tests; Middle Aged; Multilocus Sequence Typing; Otitis Media; Penicillins; Pneumococcal Infections; Pneumococcal Vaccines; Prevalence; Serogroup; Serotyping; Streptococcus pneumoniae; Sulfamethoxazole; Taiwan; Trimethoprim; Vaccines, Conjugate; Young Adult | - |
dc.title | Acute otitis media caused by Streptococcus pneumoniae serotype 19A ST320 clone: epidemiological and clinical characteristics | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jmii.2016.08.002 | - |
dc.identifier.pmid | 28087317 | - |
dc.identifier.scopus | 2-s2.0-85009499723 | - |
dc.relation.pages | 337-343 | - |
dc.relation.journalvolume | 51 | - |
dc.relation.journalissue | 3 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | National Taiwan University Children's Hospital | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0002-9291-260X | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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