|Title:||Age-specific cut-offs for the tuberculin skin test to detect latent tuberculosis in BCG-vaccinated children||Authors:||Chan P.-C.
|Issue Date:||2008||Journal Volume:||12||Journal Issue:||12||Start page/Pages:||1401-1406||Source:||International Journal of Tuberculosis and Lung Disease||Abstract:||
OBJECTIVE: To evaluate the effect of neonatal vaccination with bacille Calmette-Gu?rin (BCG) on tuberculin skin test (TST) reactivity over time and to define the optimal age-specific induration cut-offs to detect latent tuberculosis infection (LTBI). DESIGN: TSTs were performed on 783 children aged 3 months to 14 years who had received neonatal BCG. The estimated annual risk of LTBI was derived from TSTs administered to 2504 children aged 7 years who lacked BCG scars. Goodness-of-fit analysis was used to determine the optimal age-specific cut-off values. RESULTS: The effect of neonatal BCG on TST induration waned with age, reaching a nadir at age 6-7 years. This was followed by a rise in TST reactivity. The optimal age-specific TST cut-off values for the detection of LTBI was estimated to be respectively 21, 18, 13 and 10 mm at ages 0-1, 2-3, 4-5 and 6-7 years. There was a close correlation between these new cut-off values with the estimated risk of LTBI for the first 7 years of life (r = 0.93, P < 0.001). CONCLUSIONS: The effect of neonatal BCG on TST gradually declines over the first 7 years of life. Our proposed new age-specific TST induration cut-off values could help differentiate between response to BCG and LTBI in young children. ? 2008 The Union.
|ISSN:||1027-3719||SDG/Keyword:||BCG vaccine; adolescent; age distribution; article; BCG vaccination; child; controlled study; female; human; infant; major clinical study; male; priority journal; tuberculin test; tuberculosis; Adolescent; Age Factors; BCG Vaccine; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Tuberculin Test; Tuberculosis; Vaccination
|Appears in Collections:||醫學系|
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