https://scholars.lib.ntu.edu.tw/handle/123456789/566556
標題: | The transforming Streptococcus pneumoniae in the 21st century | 作者: | Hsieh Y.-C. Lee W.-S. PEI-LAN SHAO LUAN-YIN CHANG LI-MIN HUANG |
公開日期: | 2008 | 卷: | 31 | 期: | 2 | 起(迄)頁: | 117-124 | 來源出版物: | Chang Gung Medical Journal | 摘要: | Streptococcus pneumoniae, an important pathogen causing sepsis, sinusitis, otitis media, bacterial meningitis and bacterial pneumonia, results in global morbidity and mortality each year. The burden of pneumococcal disease is highest in children and the elderly. Treatment of pneumococcal infection has been hampered by the complexity of the host immune response. In recent decades, the increase of S. pneumoniae strains' resistance to β-lactam antibiotics and other classes of antimicrobials has made treatment even more complicated. Fortunately, the advent of heptavalent conjugate vaccine confers a high degree of protection against pneumococcal disease and colonization caused by vaccine serotype strains. After the introduction of conjugate pneumococcal vaccine, invasive pneumococcal disease caused by vaccine serotypes and antibiotic-resistant isolates has been reduced. However, naturally transformable pneumococci may escape vaccine-induced immunity by switching their capsular genes to non-vaccine serotypes. Development of cheaper, serotype-independent vaccines based on a combination of protein antigens should be pursued. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-42449156284&partnerID=40&md5=6a649f52511e02904ba5db345b399934 https://scholars.lib.ntu.edu.tw/handle/123456789/566556 |
ISSN: | 0255-8270 | SDG/關鍵字: | autolysin; beta lactam antibiotic; C reactive protein; choline binding protein; complement; Pneumococcus vaccine; pneumolysin; surfactant protein A; toll like receptor; unclassified drug; virulence factor; antibiotic resistance; bacterial colonization; bacterial meningitis; bacterial virulence; bacterium transformation; evolution; human; immunization; innate immunity; morbidity; mortality; nonhuman; otitis media; review; sepsis; serotyping; sinusitis; Streptococcus infection; Streptococcus pneumonia; Streptococcus pneumoniae; Immunity, Natural; Pneumococcal Vaccines; Streptococcus pneumoniae; Transformation, Bacterial; Virulence Factors |
顯示於: | 醫學系 |
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