https://scholars.lib.ntu.edu.tw/handle/123456789/566631
標題: | An open study of inactivated hepatitis A vaccine (VAQTA) in Taiwanese healthy adult volunteers: Safety, tolerability, and immunogenicity | 作者: | Yang C.-Y. CHUN-YI LU CHIN-YUN LEE PEI-LAN SHAO Wang C.-Y. Wu T.-Z. LI-MIN HUANG |
公開日期: | 2004 | 卷: | 37 | 期: | 4 | 起(迄)頁: | 216-218 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | The safety, tolerability and immunogenicity of inactivated hepatitis A vaccine (VAQTA, Merck and Co. Inc., West Point, PA, USA) were investigated in 28 seronegative healthy adult volunteers. The age range was 25-35 years, and the mean age was 29 years. Two doses of the vaccine, each containing 50 U of hepatitis A virus antigen, were administered into the deltoid region 24 weeks apart. No serious vaccine-related adverse reactions were reported. Four weeks after the first dose, the geometric mean titer (GMT) was 150 mlU/mL, and the seroconversion rate was 100%. Twenty eight weeks after the first dose (4 weeks following the second dose), the GMT was 4576 mIU/mL. This study demonstrated that VAQTA is safe and highly immunogenic in healthy young adults in Taiwan. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-4644226377&partnerID=40&md5=6be7efd06f5d5f347e332872acd96dd4 https://scholars.lib.ntu.edu.tw/handle/123456789/566631 |
ISSN: | 1684-1182 | SDG/關鍵字: | hepatitis A antigen; hepatitis A vaccine; inactivated vaccine; adult; antibody blood level; antibody titer; article; drug dose regimen; drug efficacy; drug safety; drug screening; drug tolerability; erythema; fatigue; female; hepatitis A; Hepatitis A virus; human; human experiment; immunogenicity; injection pain; male; normal human; open study; seroconversion; Taiwan; Adult; Antibodies, Viral; Drug Tolerance; Female; Hepatitis A Vaccines; Hepatitis A virus; Humans; Male; Safety; Time Factors; Vaccines, Inactivated |
顯示於: | 醫學系 |
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