https://scholars.lib.ntu.edu.tw/handle/123456789/566639
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang C.-Y. | en_US |
dc.contributor.author | Lu C.-Y. | en_US |
dc.contributor.author | Hsieh Y.-C. | en_US |
dc.contributor.author | CHIN-YUN LEE | en_US |
dc.contributor.author | LI-MIN HUANG | en_US |
dc.date.accessioned | 2021-06-24T07:19:48Z | - |
dc.date.available | 2021-06-24T07:19:48Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-1842732534&partnerID=40&md5=537bc24937f2e9ee4d5fef11c4ff72d0 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/566639 | - |
dc.description.abstract | In order to evaluate the clinical efficacy and safety profiles of single-dose ceftriaxone (50 mg/kg, not exceeding 1g) and a 10-day course of amoxicillin-clavulanate (amoxi-clav) [45 mg/kg/day, in 3 divided doses] in children with acute otitis media (AOM), we conducted a prospective, comparative, randomized trial. Between February 2000 and April 2002, 110 children with a mean age of 30.73 ± 20.79 months were enrolled. 109 patients were evaluated for the safety assessment. The intent-to treat population included 96 patients who completed at least 3 days of treatment. The standard analysis population included 73 patients who completed the 10-day treatment period without any major violation. For the standard analysis population, 57 out of 73 patients experienced treatment success; 31 out of 41 patients in the ceftriaxone group were cured compared with 25 out of 32 patients in the amoxi-clav group. The rate of persistence of middle-ear fluid did not differ between the 2 groups at day 11 or day 28. A higher treatment preference rate was observed in the ceftriaxone group (93.9% vs 58.6%). The most common drug-related adverse effects were found in the digestive system, skin and appendages in both treatment groups. A single dose of ceftriaxone is as safe and effective as amoxi-clav for curing patients with acute otitis media. In addition, a substantially higher proportion of patients receiving single-dose ceftriaxone showed a preference for the study medication compared with those treated with amoxi-clav for 10 days. | en_US |
dc.relation.ispartof | Journal of Microbiology, Immunology and Infection | en_US |
dc.subject | Amoxicillin-clavulanate combination; Ceftriaxone; Infant; Preschool child | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | amoxicillin plus clavulanic acid; ceftriaxone; acute disease; article; clinical trial; controlled clinical trial; controlled study; convalescence; diarrhea; digestive system disease; drug efficacy; drug safety; evaluation; female; human; infant; liquid; major clinical study; male; otitis media; pediatrics; preschool child; prospective study; randomized controlled trial; rash; side effect; single drug dose; skin appendage disease; skin disease; standardization; treatment outcome; Acute Disease; Administration, Oral; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Ceftriaxone; Child; Child, Preschool; Female; Humans; Infant; Injections, Intramuscular; Male; Otitis Media; Prospective Studies; Treatment Outcome | - |
dc.title | Intramuscular ceftriaxone in comparison with oral amoxicillin-clavulanate for the treatment of acute otitis media in infants and children | en_US |
dc.type | journal article | en_US |
dc.identifier.pmid | 15060689 | - |
dc.identifier.scopus | 2-s2.0-1842732534 | - |
dc.relation.pages | 57-62 | en_US |
dc.relation.journalvolume | 37 | en_US |
dc.relation.journalissue | 1 | en_US |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | National Taiwan University Children's Hospital | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0002-3938-377X | - |
crisitem.author.orcid | 0000-0002-9291-260X | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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