|Title:||A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX? in healthy children||Authors:||Lau Y.-L.
|Keywords:||Immunogenicity; Varicella vaccination; Varicella zoster virus||Issue Date:||2002||Journal Volume:||20||Journal Issue:||23-24||Start page/Pages:||2942-2949||Source:||Vaccine||Abstract:||
This study compared safety, tolerability, and immunogenicity of the Oka/Merck varicella vaccine and VARILRIX? [Oka-RIT strain SmithKline Beecham Biologicals] in healthy children 12-24 months of age. Subjects were randomized in this double blind study to receive either a single dose of Oka/Merck varicella vaccine, (?50,000 plaque forming units (PFU), Group A or ?16,000PFU, Group B) or 1 dose of VARILRIX?, (?40,000PFU/dose, Group C). Safety profiles in each treatment group were similar. The proportions of subjects achieving a 6-week postvaccination titer ?5 gpELISA units in Groups A, B or C were 97.1, 95.2 and 85.6%, respectively. ? 2002 Elsevier Science Ltd. All rights reserved.
|ISSN:||0264-410X||DOI:||10.1016/S0264-410X(02)00245-1||metadata.dc.subject.other:||chickenpox vaccine; measles mumps rubella vaccine; mmr; varicella zoster vaccine; chickenpox vaccine; live vaccine; virus antibody; chickenpox; clinical trial; conference paper; controlled clinical trial; controlled study; death; double blind procedure; drug safety; drug tolerability; ecchymosis; enzyme linked immunosorbent assay; erythema; female; human; human experiment; immunogenicity; male; multicenter study; normal human; preschool child; priority journal; randomized controlled trial; rash; side effect; vaccination; Varicella zoster virus; virus titration; article; blood; comparative study; drug tolerance; immunology; infant; safety; Antibodies, Viral; Chickenpox Vaccine; Comparative Study; Double-Blind Method; Drug Tolerance; Enzyme-Linked Immunosorbent Assay; Female; Herpesvirus 3, Human; Human; Infant; Male; Safety; Support, Non-U.S. Gov't; Vaccines, Attenuated; Antibodies, Viral; Double-Blind Method; Drug Tolerance; Enzyme-Linked Immunosorbent Assay; Female; Herpesvirus 3, Human; Humans; Infant; Male; Safety; Vaccines, Attenuated
|Appears in Collections:||醫學系|
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