https://scholars.lib.ntu.edu.tw/handle/123456789/566691
標題: | Viral etiology of intussusception in Taiwanese childhood | 作者: | HONG-YUAN HSU CHUAN-LIANG KAO LI-MIN HUANG YEN-HSUAN NI HONG-SHIEE LAI Lin F.-Y. MEI-HWEI CHANG |
公開日期: | 1998 | 卷: | 17 | 期: | 10 | 起(迄)頁: | 893-898 | 來源出版物: | Pediatric Infectious Disease Journal | 摘要: | Background. Adenovirus infection and lymphoid hyperplasia have been associated with childhood intussusception. However, the extent of other viruses involved in this condition remains unclear. This prospective study investigates the relationship between some lymphotropic viruses and current childhood intussusception. Methods. Patients with intussusception encountered in a pediatric emergency department in a recent 3-year period were studied. Healthy infants and toddlers of comparable age served as controls. Throat and rectal viral cultures were performed in patients and controls. Viral antibodies against adenovirus, cytomegalovirus, human herpesvirus (HIV-6, HHV-7 and Epstein-Bart virus (EBV) were tested in paired sera from the patients. Acute stage serum from each patient and mesenteric lymph nodes from patients requiring surgery were studied for the presence of adenovirus genome by PCR. Results. Twenty-seven of 61 (44.3%) intussusception patients, but only 2 of 52 (3.8%) healthy controls shed nonenteric adenovirus in throat and rectal specimens (P < 0.001). Of the 27 (74.1%) patients who shed adenovirus, 20 were older than I year old, whereas only 1 of 15 (6.7%) similarly aged patients in a previous study from the same area three decades ago did so (P = 0.001). Among 43 patients with available paired sera, acute primary viral infection was found in 17 (39.5%) by adenovirus, 4 (9.3%) by HHV-6, 5 (11.6%) by HHV-7, 2 (4.7%) by EBV and none by cytomegalovirus. Multiple viral infections occurred in 6 patients. Adenovirus genome was detected in 4 of 9 roesenteric lymph nodes and in only 3 of 60 (5%) acute phase sera. Conclusions. Primary nonenteric adenovirus infection contributes to current childhood intussusception. Acute primary HHV-6, HHV-7 and EBV infections also play etiologic roles. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031733302&doi=10.1097%2f00006454-199810000-00009&partnerID=40&md5=5c0b2d800460572b67f64130e5da228e https://scholars.lib.ntu.edu.tw/handle/123456789/566691 |
ISSN: | 0891-3668 | DOI: | 10.1097/00006454-199810000-00009 | SDG/關鍵字: | immunoglobulin g; immunoglobulin m; virus antibody; age distribution; antibody detection; article; child; controlled study; epstein barr virus; female; human; human herpesvirus 6; human herpesvirus 7; infant; intussusception; lymphoid hyperplasia; major clinical study; male; mesentery lymph node; polymerase chain reaction; priority journal; taiwan; throat culture; virus characterization; virus culture; virus genome; virus infection; virus shedding; Acute-Phase Reaction; Adenoviridae; Adenoviridae Infections; Antibodies, Viral; Child; Child, Preschool; Female; Herpesviridae Infections; Herpesvirus 6, Human; Herpesvirus 7, Human; Humans; Infant; Intussusception; Male; Polymerase Chain Reaction; Prospective Studies; Taiwan |
顯示於: | 醫學系 |
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