https://scholars.lib.ntu.edu.tw/handle/123456789/567391
標題: | Identification of serum cytokine clusters associated with outcomes in ovarian clear cell carcinoma | 作者: | Yabuno A. Matsushita H. Hamano T. Tan T.Z. Shintani D. Fujieda N. Tan D.S.P. RUBY YUN-JU HUANG Fujiwara K. Kakimi K. Hasegawa K. |
公開日期: | 2020 | 出版社: | Nature Research | 卷: | 10 | 期: | 1 | 起(迄)頁: | 18503 | 來源出版物: | Scientific Reports | 摘要: | Serum cytokine and chemokine networks may reflect the complex systemic immunological interactions in cancer patients. Studying groups of cytokines and their networks may help to understand their clinical biology. A total of 178 cases of ovarian cancer were analyzed in this study, including 73 high-grade serous (HGSC), 66 clear cell (CCC) and 39 endometrioid carcinomas. Suspension cytokine arrays were performed with the patients’ sera taken before the primary surgery. Associations between each cytokine and clinicopathological factors were analyzed in all patients using multivariate linear regression models, and cluster analyses were performed for each histotype. In the multivariate analyses, twelve of 27 cytokines were correlated with histotypes. Cluster analyses in each histotype revealed 2 cytokine signatures S1 and S2 in HGSC, and similarly C1 and C2 in CCC. Twenty-two of 27 cytokines were commonly clustered in HGSC and CCC. Signature S1 and C1 included IL-2,6,8,15, chemokines and angiogenic factors, whereas signature S2 and C2 included IL-4,5,9,10,13, TNF-α and G-CSF. Four subgroups based on a high or low level for each signature were identified, and this cluster-based classification demonstrated significantly different progression-free and overall survivals for CCC patients (P = 0.00097 and P = 0.017). ? 2020, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094201277&doi=10.1038%2fs41598-020-75536-1&partnerID=40&md5=172e7e1a8dd3c2b7a4db4a33ef3a308d https://scholars.lib.ntu.edu.tw/handle/123456789/567391 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-75536-1 | SDG/關鍵字: | cytokine; tumor marker; adenocarcinoma; adult; aged; blood; cystadenocarcinoma; endometrioid carcinoma; female; human; immunology; metabolism; middle aged; ovary; ovary tumor; pathology; Adenocarcinoma, Clear Cell; Adult; Aged; Biomarkers, Tumor; Carcinoma, Endometrioid; Carcinoma, Ovarian Epithelial; Cystadenocarcinoma, Serous; Cytokines; Female; Humans; Middle Aged; Ovarian Neoplasms; Ovary |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。