https://scholars.lib.ntu.edu.tw/handle/123456789/567532
標題: | One-year weight management lowers lipopolysaccharide-binding protein and its implication in metainflammation and liver fibrosis | 作者: | Nien H.-C. JIN-CHUAN SHEU Chi Y.-C. CHI-LING CHEN JIA-HORNG KAO WEI-SHIUNG YANG |
公開日期: | 2018 | 出版社: | Public Library of Science | 卷: | 13 | 期: | 11 | 起(迄)頁: | e0207882 | 來源出版物: | PLoS ONE | 摘要: | Background Studies showed that the endotoxemia-related biomarker, lipopolysaccharide-binding protein (LBP), is associated with obesity and fatty liver. The level of LBP is reduced after surgical weight loss. This study aimed to verify the change of serum LBP levels after one-year medical weight management in subjects with obesity. Methods and findings A total of 62 subjects with obesity, 39 subjects with overweight, and 21 subjects with normal body mass index were enrolled for a one-year weight management program. Basic information, body composition analysis, clinical data, serum LBP level, and abdominal ultrasonogra-phy findings were collected. At baseline, the serum LBP levels of the obese and overweight subjects were significantly higher than that of the normal group (30.9±7.4 and 29.6±6.3 versus 23.1±5.6 μg/mL, respectively, p<0.001). Serum LBP in subjects with obesity was significantly reduced to 26.5±7.1 μg/mL (p-value < 0.001) after one year. In the multivariate analyses, LBP was associated with high sensitive C-reactive protein (hs-CRP) and nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) before weight management in the obese group. Moreover, the change of LBP in response to weight management was significantly related to the changes of hs-CRP, leukocyte count and NFS by multivariate linear regression analysis also in the obese group. Conclusion The serum level of the endotoxemia-related biomarker, LBP, decreases after one-year weight management in the obese subjects. In addition to serving as a metainflammatroy biomarker like hs-CRP, LBP may also be a potential biomarker as a non-invasive biomarker for the evaluation of liver fibrosis in NAFLD. ? 2018 Nien et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056802145&doi=10.1371%2fjournal.pone.0207882&partnerID=40&md5=8896680e7bbb0ae2f7b8715e020a5986 https://scholars.lib.ntu.edu.tw/handle/123456789/567532 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0207882 | SDG/關鍵字: | alanine aminotransferase; alpha fetoprotein; aspartate aminotransferase; C peptide; C reactive protein; gamma glutamyltransferase; hemoglobin A1c; hepatitis B surface antigen; high density lipoprotein cholesterol; hydrocortisone; insulin; lipopolysaccharide binding protein; low density lipoprotein cholesterol; thyrotropin; thyroxine; uric acid; acute phase protein; carrier protein; lipopolysaccharide-binding protein; membrane protein; adult; Article; blood sampling; body composition; body height; body mass; body weight; body weight loss; body weight management; cohort analysis; disease association; echography; endotoxemia; fasting; fat mass; fatty liver; female; follow up; free thyroxine index; hepatitis B; human; hyperlipidemia; hypertension; intra-abdominal fat; leukocyte count; lifestyle modification; linear regression analysis; liver fibrosis; major clinical study; male; metabolic syndrome X; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; obesity; waist circumference; waist hip ratio; blood; clinical trial; inflammation; liver cirrhosis; middle aged; weight loss program; Acute-Phase Proteins; Carrier Proteins; Female; Humans; Inflammation; Liver Cirrhosis; Male; Membrane Glycoproteins; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity; Weight Reduction Programs |
顯示於: | 醫學系 |
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