https://scholars.lib.ntu.edu.tw/handle/123456789/567651
標題: | Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3 | 作者: | Huang S.-J. WEI-SHIUNG YANG Lin Y.-W. Wang H.-C. Chen C.-C. |
關鍵字: | Aging; APETx2; ASIC3; Glucose tolerance; Insulin; WAT | 公開日期: | 2008 | 卷: | 371 | 期: | 4 | 起(迄)頁: | 729-734 | 來源出版物: | Biochemical and Biophysical Research Communications | 摘要: | Glucose tolerance progressively declines with age in humans and is often accompanied by insulin resistance and a high prevalence of type 2 diabetes. Little is known about the mechanism underlying the age-related changes in glucose metabolism. Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally expressed in adipose cells. ASIC3-/- mice were protected against age-dependent glucose intolerance with enhanced insulin sensitivity. Acute administration of ASIC3-selective blocker APETx2 improved the glucose control and increased the insulin sensitivity in older (25-27 weeks) ASIC3+/+ mice. Moreover, the enhanced glucose control in aging ASIC3-/- mice was associated with high baseline levels of Akt phosphorylation and high copy number of mitochondrial DNA in adipose tissues. Taken together, our data suggest that ASIC3 signaling might be involved in the control of age-dependent glucose intolerance and insulin resistance. ? 2008 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-44149123309&doi=10.1016%2fj.bbrc.2008.04.147&partnerID=40&md5=f205f2556b18a03234256fb87cb1cbf0 https://scholars.lib.ntu.edu.tw/handle/123456789/567651 |
ISSN: | 0006-291X | DOI: | 10.1016/j.bbrc.2008.04.147 | SDG/關鍵字: | acid sensing ion channel; acid sensing ion channel 3; APETx2; glucose; insulin; mitochondrial DNA; peptide; protein kinase B; sea anemone toxin; adipose tissue; adipose tissue cell; aging; animal cell; animal experiment; animal tissue; article; female; glucose intolerance; glycemic control; insulin resistance; insulin sensitivity; mouse; nonhuman; priority journal; protein phosphorylation; signal transduction; Adipose Tissue; Age Factors; Animals; Cnidarian Venoms; Glucose Intolerance; Insulin Resistance; Mice; Mice, Knockout; Signal Transduction; Sodium Channels; Mus |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。