https://scholars.lib.ntu.edu.tw/handle/123456789/567954
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | YAO-HSU YANG | en_US |
dc.contributor.author | CHIEN-CHANG LEE | en_US |
dc.contributor.author | Huang C.-L. | en_US |
dc.contributor.author | LI-CHIEH WANG | en_US |
dc.contributor.author | BOR-LUEN CHIANG | en_US |
dc.date.accessioned | 2021-07-02T03:42:15Z | - |
dc.date.available | 2021-07-02T03:42:15Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847694008&partnerID=40&md5=f77a61f3df512f53bbb4ee8d40e551dc | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/567954 | - |
dc.description.abstract | Background and Purpose: Depending on the severity of the illness, thrombocytosis is found in about 60% to 70% of patients with Henoch-Sch?nlein purpura (HSP). Whether thrombocytosis is the result of an inflammatory reaction mediated by thrombopoietin (TPO) or other inflammatory cytokines such as interleukin (IL)-6 remains unknown. Methods: Thirty two patients who met the diagnostic criteria for HSP were included. They were divided into two groups - HSP patients with thrombocytosis (n = 14) and those without thrombocytosis (n = 18) with a platelet count of 400,000/μL. Eight normal healthy controls were also included. TPO and IL-6 serum levels during the acute phase were measured by enzyme-linked immunosorbent assay. Results: Patients with platelet counts greater than 400,000/μL in the acute stage had significantly lower TPO levels than patients with platelet counts lower than 400,000/μL (310 ± 65.6 pg/mL vs 608 ± 97.8 pg/mL, p=0.013). However, HSP patients with or without thrombocytosis had similar TPO levels as the healthy controls (441 ± 176 pg/mL, p=0.89 and 0.29, respectively). IL-6 serum levels were significantly elevated in HSP patients during the acute stage of HSP (28.6 ± 61.7 pg/mL vs 3.16 ± 1.35 pg/mL, p=0.049). In patients with complications of glomerulonephritis or gastrointestinal hemorrhage (n = 12), IL-6 levels were significantly lower than in those without such complications (8.07 ± 3.79 pg/mL vs 40.9 ± 16.9 pg/mL, p=0.007). Conclusions: This study showed that thrombocytosis in HSP patients is a type of inflammatory reactive thrombocytosis, and that IL-6 may also play a role in the pathogenesis of HSP. ? 2006 Journal of Microbiology, Immunology and Infection. | en_US |
dc.relation.ispartof | Journal of Microbiology, Immunology and Infection | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | interleukin 6; thrombopoietin; interleukin 6; thrombopoietin; anaphylactoid purpura; article; child; clinical article; controlled study; disease severity; enzyme linked immunosorbent assay; female; gastrointestinal hemorrhage; glomerulonephritis; human; infant; inflammation; male; thrombocyte count; thrombocytosis; anaphylactoid purpura; blood; pathophysiology; preschool child; Taiwan; teaching hospital; thrombocytosis; Child; Child, Preschool; Female; Hospitals, Teaching; Humans; Infant; Interleukin-6; Male; Platelet Count; Purpura, Schoenlein-Henoch; Taiwan; Thrombocytosis; Thrombopoietin | - |
dc.title | Thrombopoietin and interleukin-6 levels in Henoch-Schönlein purpura | en_US |
dc.type | journal article | en |
dc.identifier.pmid | 17164950 | - |
dc.identifier.scopus | 2-s2.0-33847694008 | - |
dc.relation.pages | 476-482 | en_US |
dc.relation.journalvolume | 39 | en_US |
dc.relation.journalissue | 6 | en_US |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Emergency Medicine | - |
crisitem.author.dept | Emergency Medicine-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | College of Life Science | - |
crisitem.author.dept | Immunology | - |
crisitem.author.orcid | 0000-0002-6266-9864 | - |
crisitem.author.orcid | 0000-0002-1243-2463 | - |
crisitem.author.orcid | 0000-0002-5773-1627 | - |
crisitem.author.orcid | 0000-0002-6705-0286 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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