https://scholars.lib.ntu.edu.tw/handle/123456789/568101
標題: | Administration of interleukin-12 prevents mite Der p 1 allergen-IgE antibody production and airway eosinophil infiltration in an animal model of airway inflammation | 作者: | Lee Y.-L. Fu C.-L. Ye Y.-L. BOR-LUEN CHIANG |
公開日期: | 1999 | 卷: | 49 | 期: | 3 | 起(迄)頁: | 229-236 | 來源出版物: | Scandinavian Journal of Immunology | 摘要: | The aim of the present study was to examine the in vivo effect of interleukin (IL)-12 on a murine model of asthma induced by Dermatophagoides pteronyssinus-derived Der p 1 allergen. C57BL/6 mice immunized with Der p 1 allergen adsorbed to alum/pertussis toxin developed a T-helper type 2 (Th2)- dominant immune response characterized by the presence of IgE antibody, airway eosinophil infiltration and increased production of Th2 cytokine. Intraperitoneal injection of IL-12 (1 or 0.1 μg per day) for 5 days (day - 1 to + 3) simultaneously with each immunization, inhibited the production of IgE and IgG1 antigen-specific antibodies, whereas production of IgG(2a) was strongly enhanced. In addition, mice receiving both doses of IL-12 showed a strong inhibition of IL-5 but up-regulation of IFN-γ production by spleen cells stimulated with antigen. Administration of IL-12 also prevented antigen-induced eosinophil infiltration into the bronchoalveolar area in a dose-dependent manner and the primary inflammatory mediator serotonin in bronchoalveolar lavage (BAL) fluids was also reduced significantly. Taken together, the data indicate that IL-12 has a potent immunomodulatory effect on house-dust-mite-induced allergic disorders and may be used as an efficient agent for immunotherapy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033049930&doi=10.1046%2fj.1365-3083.1999.00503.x&partnerID=40&md5=3fae0588140c62ddb32e307f0326c9a3 https://scholars.lib.ntu.edu.tw/handle/123456789/568101 |
ISSN: | 0300-9475 | DOI: | 10.1046/j.1365-3083.1999.00503.x | SDG/關鍵字: | house dust allergen; immunoglobulin e; interleukin 12; animal experiment; animal model; antibody production; article; asthma; cell infiltration; drug effect; drug potency; eosinophil; female; immune response; immunomodulation; lung lavage; mouse; nonhuman; priority journal; respiratory tract inflammation; Allergens; Animals; Antigens, Dermatophagoides; Asthma; Cytokines; Disease Models, Animal; Eosinophils; Female; Glycoproteins; Humans; Immunoglobulin E; Immunoglobulin G; Immunotherapy; Inflammation; Interleukin-12; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mites; Respiratory System; Th1 Cells; Th2 Cells |
顯示於: | 醫學系 |
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