https://scholars.lib.ntu.edu.tw/handle/123456789/568362
標題: | Chronologic changes in serum hepatitis B virus DNA, genotypes, surface antigen mutants and reverse transcriptase mutants during 25-year nationwide immunization in Taiwan | 作者: | HONG-YUAN HSU MEI-HWEI CHANG YEN-HSUAN NI Chiang C.-L. JIA-FENG WU HUEY-LING CHEN PEI-JER CHEN Chen D.-S. |
公開日期: | 2017 | 出版社: | Blackwell Publishing Ltd | 卷: | 24 | 期: | 8 | 起(迄)頁: | 645-653 | 來源出版物: | Journal of Viral Hepatitis | 摘要: | We investigated breakthrough infection and hepatitis B virus (HBV) genetic changes in immunized subjects after 25?years of a universal infant immunization. Specifically, serum HBV DNA, genotypes, surface antigen mutants and nucleoside analog-resistant (NAr) mutants were assessed in 2853 subjects (<25?years old) surveyed in 2009, and these data were compared with the data from previous serosurveys. A comparison across different age-stratified groups using the 2009 data revealed a significant increase in the seropositive rate of anti-HBc (5.51% vs 12.38%, P=.001) and HBV DNA (1.13% vs 3.96%, P=.007) between those 17-22 and 23-24?years of age, possibly due to selective infant immunization in 1984-1986. Well-characterized NAr mutants, potential NAr mutants and surface “a” determinant mutants were detected in none, 15 (45.5%) and nine (27.3%) of 33 HBV DNA-positive subjects, respectively. Of 15 immunized, HBV DNA-positive young adults (18-24?years), three (20%) carried “a” determinant mutants. Amongst 1176 HBsAg-negative subjects evaluated for occult HBV infection, those seropositive for anti-HBc had a higher seropositive rate for HBV DNA (10/110, 9.1% vs 7/1066, 0.66%; P<.001) and “a” determinant mutants (4/110, 3.6% vs 0/1066; P<.001) than those seronegative for anti-HBc. Overall, the HBsAg-positive subjects in six serosurveys showed no significant increase in genotype C frequency in the comparison between the vaccinated and unvaccinated cohorts (25/98, 25.5% versus 14/79, 17.7%, P=.188). Over the 25-year programme, there was no increase in the prevalence of genotype C in HBsAg carriers and no increase in breakthrough HBV infection or surface mutant prevalence beyond adolescence. Nucleic acid amplification should still be considered the primary screening method for occult hepatitis B detection in high-risk recipients. ? 2017 John Wiley & Sons Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014772699&doi=10.1111%2fjvh.12687&partnerID=40&md5=390c68d4d064b48d6fd22995f371d9b1 https://scholars.lib.ntu.edu.tw/handle/123456789/568362 |
ISSN: | 1352-0504 | DOI: | 10.1111/jvh.12687 | SDG/關鍵字: | hepatitis B core antibody; hepatitis B surface antigen; hepatitis B vaccine; nucleoside analog; RNA directed DNA polymerase; virus DNA; hepatitis B surface antigen; hepatitis B vaccine; mutant protein; RNA directed DNA polymerase; virus DNA; adolescent; adult; age; antiviral resistance; Article; child; cohort analysis; female; genotype; health survey; hepatitis B; Hepatitis B virus; high risk patient; human; immunization; infant; major clinical study; male; nucleic acid amplification; preschool child; prevalence; priority journal; school child; Taiwan; virus mutant; young adult; chronic hepatitis B; classification; genetics; isolation and purification; serum; time factor; virology; Adolescent; Child; Child, Preschool; DNA, Viral; Female; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Male; Mutant Proteins; RNA-Directed DNA Polymerase; Serum; Taiwan; Time Factors; Young Adult |
顯示於: | 臨床醫學研究所 |
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