https://scholars.lib.ntu.edu.tw/handle/123456789/568533
標題: | Serum p53 gene polymorphisms and severity of hepatitis B or C-related chronic liver diseases in Taiwan | 作者: | Mah Y.-H. Hsu C.-S. CHEN-HUA LIU CHUN-JEN LIU Lai M.-Y. PEI-JER CHEN DING-SHINN CHEN JIA-HORNG KAO |
公開日期: | 2011 | 出版社: | Springer New York LLC | 卷: | 5 | 期: | 3 | 起(迄)頁: | 814-821 | 來源出版物: | Hepatology International | 摘要: | Background and aims: Polymorphisms of p53 gene are known to play an important role in hepatocarcinogenesis. We aimed to investigate the impact of p53 polymorphisms on disease progression by evaluating their prevalence among chronic hepatitis B (CHB) or hepatitis C (CHC) patients with different stages of liver disease. Methods: A total of 215 CHB, 108 CHC patients with different stages of liver disease and 49 healthy controls were consecutively enrolled. The codon 249 p53 mutations as well as codon 72 polymorphisms were assayed by molecular methods, and their prevalence among the enrolled subjects was evaluated. Results: All patients and controls had codon 249 wild-type sequences. Among codon 72 sequences, Pro/Pro allele frequency of Hepatitis B-related HCC (31.4%), cirrhosis (26.9%), HBV carriers (26.3%), hepatitis C-related cirrhosis (39.1%), and CHC patients (24%) were higher than that of healthy controls (18.4%). After adjustment for sex and age, codon 72 mutant and mixed type were associated with a higher likelihood of asymptomatic carrier state than those with wild type in CHB patients [odd ratio (OR): 2.53, 95% confidence interval (CI) 1.06-6.03, P = 0.037]. However, the prevalence of codon 72 mutant and mixed type were comparable with wild type among CHC patients with HCC (OR 0.70, 95% CI 0.28-1.72, P = 0.433). Conclusions: Although serum 249serine p53 mutation is rarely found in Taiwanese patients, HBV carriers have a higher prevalence of codon 72 mutants than patients with much severe liver diseases or HCV infection, which implies that codon 72 mutants may affect at an earlier stage of HBV infection. Further studies are necessary to delineate the interactions of p53 mutations with HBV infection. ? Asian Pacific Association for the Study of the Liver 2011. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984549647&doi=10.1007%2fs12072-010-9248-5&partnerID=40&md5=b121b2dca055432097b32ab18c10834a https://scholars.lib.ntu.edu.tw/handle/123456789/568533 |
ISSN: | 1936-0533 | DOI: | 10.1007/s12072-010-9248-5 | SDG/關鍵字: | arginine; proline; serine; amino acid substitution; article; blood analysis; chronic liver disease; codon; controlled study; disease severity; DNA polymorphism; female; gene frequency; gene interaction; gene mutation; gene sequence; genetic association; hepatitis B; hepatitis C; heterozygosity; homozygosity; human; human tissue; major clinical study; male; mutator gene; p53 gene; priority journal; Taiwan; wild type |
顯示於: | 臨床醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。