https://scholars.lib.ntu.edu.tw/handle/123456789/568566
標題: | Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan | 作者: | Huang Y.-W. Liao Y.-T. Chen W. CHI-LING CHEN Hu J.-T. CHUN-JEN LIU Lai M.-Y. PEI-JER CHEN DING-SHINN CHEN Yang S.-S. JIA-HORNG KAO |
公開日期: | 2010 | 出版社: | Nature Publishing Group | 卷: | 11 | 期: | 1 | 起(迄)頁: | 87-93 | 來源出版物: | Genes and Immunity | 摘要: | Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers. We genotyped the BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) polymorphisms of VDR gene in 250 Taiwanese chronic hepatitis B virus (HBV) carriers who were categorized into six phenotypes. After adjustment for age and sex, the frequencies of the VDR B/b, B/a, B/T, B/a/T in patients with hepatitis flare(s) were lower than those without (7 vs 20%, P0.009; 1 vs 9%, P0.004; 3 vs 10%, P0.007; 1 vs 9%, P0.005, respectively); in contrast, T/t, A/T, A/t, b/A/t were higher in flare(s) (8 vs 3%, P0.003; 49 vs 34%, P0.027; 2 vs 1%, P0.004; 0.5 vs 0%, P0.001, respectively). In addition, B/b, B/B, T/t, b/A, B/a, B/A, B/T, B/t, A/t, b/A/T, B/a/T, B/A/T, B/A/t, b/A/t were higher in patients positive for HBeAg. The distribution of VDR genotypes was comparable between patients with and without hepatocellular carcinoma (HCC). VDR gene polymorphisms are associated with distinct clinical phenotypes in Taiwanese HBV carriers but not with HCC development. ? 2010 Macmillan Publishers Limited. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984555556&doi=10.1038%2fgene.2009.65&partnerID=40&md5=2ab9267e3353d32b2c1b41e499f45769 https://scholars.lib.ntu.edu.tw/handle/123456789/568566 |
ISSN: | 1466-4879 | DOI: | 10.1038/gene.2009.65 | SDG/關鍵字: | hepatitis B(e) antigen; vitamin D receptor; adult; article; controlled study; disease exacerbation; female; genetic polymorphism; genotype; hepatitis B; Hepatitis B virus; human; liver cell carcinoma; major clinical study; male; mutation rate; mutational analysis; phenotype; priority journal; Taiwan; virus carrier; Hepatitis B virus |
顯示於: | 臨床醫學研究所 |
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