https://scholars.lib.ntu.edu.tw/handle/123456789/568583
標題: | IL10 and IL10 Receptor Gene Variation and Outcomes After Unrelated and Related Hematopoietic Cell Transplantation | 作者: | LI-HUI TSENG Storer B. Petersdorf E. Lin M.-T. Chien J.W. Grogan B.M. Malkki M. PEI-JER CHEN Zhao L.P. Martin P.J. Hansen J.A. |
公開日期: | 2009 | 出版社: | Lippincott Williams and Wilkins | 卷: | 87 | 期: | 5 | 起(迄)頁: | 704-710 | 來源出版物: | Transplantation | 摘要: | Background. Results of a previous study with human leukocyte antigen (HLA)-identical siblings showed individual and synergistic associations of single nucleotide polymorphisms in the promoter region of the recipient's IL10 gene and the donor's IL10 receptor β (IL-10RB) gene with development of grades III-IV acute graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation. Methods. In this study of 936 patients who had unrelated donors, genotypes of single nucleotide polymorphisms in the IL10 gene and the IL-10RB gene were evaluated as correlates with outcomes after transplantation. Results. We found no statistically significant associations of polymorphisms at positions - 3575, - 2763, - 1082, and - 592 of the IL10 gene or codon 238 of the IL10RB gene with severe acute GVHD, extensive chronic GVHD or nonrelapse mortality after hematopoietic cell transplantation. Among HLA-matched unrelated pairs, the patient's IL10/-592 genotype and donor's IL10RB/c238 genotype showed trends suggesting individual and combined associations with grades III-IV acute GVHD similar to those observed among patients with HLA-identical sibling donors. Conclusions. Although genetic variation in IL10 pathway affects risk of acute GVHD and non-relapse mortality in HLA-identical sibling transplants, the current results indicate that genetic variation in the IL10 pathway does not significant affect these outcomes in unrelated donor transplants suggesting that the strength of the alloimmune response in the latter exceeds the anti-inflammatory activity of IL10. Copyright ? 2009 by Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-65649123391&doi=10.1097%2fTP.0b013e318195c474&partnerID=40&md5=81119a5473fd23e9daa014652820d3a5 https://scholars.lib.ntu.edu.tw/handle/123456789/568583 |
ISSN: | 0041-1337 | DOI: | 10.1097/TP.0b013e318195c474 | SDG/關鍵字: | interleukin 10; interleukin 10 receptor; interleukin 10; interleukin 10 receptor; acute graft versus host disease; adult; allogeneic hematopoietic stem cell transplantation; article; chronic graft versus host disease; codon; disease severity; female; genetic association; genetic variability; genotype; hematopoietic stem cell transplantation; HLA matching; human; immune response; major clinical study; male; mortality; priority journal; receptor gene; risk assessment; single nucleotide polymorphism; donor; genetic variability; genetics; graft versus host reaction; sibling; single nucleotide polymorphism; statistics; Female; Genetic Variation; Genotype; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Interleukin-10; Male; Polymorphism, Single Nucleotide; Receptors, Interleukin-10; Siblings; Tissue Donors |
顯示於: | 臨床醫學研究所 |
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