https://scholars.lib.ntu.edu.tw/handle/123456789/568600
標題: | Oncolytic virotherapy for advanced liver tumours | 作者: | Chang J.-F. PEI-JER CHEN Sze D.Y. Reid T. Bartlett D. Kirn D.H. Liu T.-C. |
關鍵字: | Clinical trial; Gene therapy; Hepatic neoplasm; Hepatocellular carcinoma; Liver tumour; Oncolytic virus | 公開日期: | 2009 | 出版社: | Blackwell Publishing Inc. | 卷: | 13 | 期: | 7 | 起(迄)頁: | 1238-1247 | 來源出版物: | Journal of Cellular and Molecular Medicine | 摘要: | Introduction Pre-clinical studies Clinical studies Challenges for the use of virotherapy agents in liver tumour treatment Future directions Primary and metastatic neoplasms of the liver account for more than a million deaths per year worldwide. Despite decades of research, effective novel therapies for these cancers are urgently needed. Oncolytic virotherapeutics represent a novel class of pharmacophore that holds promise for the treatment of hepatic neoplasms. Cancer-specific replication is followed by oncolysis, virus spreading and infection of adjacent cancer cells. This process is then repeated. Virotherapeutics target multiple genetic pathways involved in carcino-genesis, and demonstrate activity against apoptosis-resistant tumour cells. This platform can also exploit the advantage of multiple intrinsic anti-cancer therapeutic mechanisms, combining direct viral oncolysis with therapeutic transgene expression. Recent advances in pre-clinical and clinical studies are revealing the potential of this unique therapeutic class, in particular for liver cancers. This review summarizes the available data on applying oncolytic virotherapeutics to hepatic neoplasms to date, and discusses the challenges and future directions for virotherapy. ? 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-68149176433&doi=10.1111%2fj.1582-4934.2008.00563.x&partnerID=40&md5=36194f08e32b5c5f107b3b638ee21287 https://scholars.lib.ntu.edu.tw/handle/123456789/568600 |
ISSN: | 1582-1838 | DOI: | 10.1111/j.1582-4934.2008.00563.x | SDG/關鍵字: | animal; article; clinical trial (topic); drug screening; human; liver tumor; methodology; oncolytic virotherapy; pathology; Animals; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Oncolytic Virotherapy |
顯示於: | 臨床醫學研究所 |
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