https://scholars.lib.ntu.edu.tw/handle/123456789/568636
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chou Y.-C. | en_US |
dc.contributor.author | MING-WHEI YU | en_US |
dc.contributor.author | Wu C.-F. | en_US |
dc.contributor.author | Yang S.-Y. | en_US |
dc.contributor.author | Lin C.-L. | en_US |
dc.contributor.author | CHUN-JEN LIU | en_US |
dc.contributor.author | Shin W.-L. | en_US |
dc.contributor.author | PEI-JER CHEN | en_US |
dc.contributor.author | Liaw Y.-F. | en_US |
dc.contributor.author | Chen C.-J. | en_US |
dc.date.accessioned | 2021-07-03T03:35:06Z | - |
dc.date.available | 2021-07-03T03:35:06Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0017-5749 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-38349105023&doi=10.1136%2fgut.2006.114066&partnerID=40&md5=42c7fc4aa0a01696f8e11752d8be4f3a | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/568636 | - |
dc.description.abstract | Background and aims: To investigate the temporal relationship between sequence variation in the enhancer II (EnhII), basal core promoter (BCP), and precore regions of hepatitis B virus (HBV) and the risk of hepatocellular carcinoma (HCC), we conducted a nested case-control study within a cohort of 4841 male HBV carriers who were recruited during the period 1988-1992. Methods: The HBV DNA sequence was determined in baseline blood samples taken from 132 incident cases and 204 controls. Base exchanges during follow-up in 71 cases were compared with 81 controls with samples taken during a similar length of follow-up. Results: Nine single nucleotide polymorphisms in the EnhII/BCP regions (six of which were genotype C HBV related) were associated with subsequent risk of HCC. The strength of these associations decreased as the lag time between baseline measurement and diagnosis increased over 3 years. However, an increased disease risk in subjects with BCP double variants (mostly T1762/A1764) or genotype C HBV-related variants was evident 9 years or more before diagnosis. The BCP double variants (odds ratio, 1.92 (95% confidence interval, 1.14 to 3.25)) were statistically significantly associated with HCC risk even after adjusting for alanine aminotransferase levels, antibodies against HBV e antigen, HBV genotype, HBV viral load, and other sequence variants. Longitudinal analysis indicated that the increased HCC risks for at-risk sequence variants were attributable to the persistence of these variants. Conclusions: HCC risk is associated with sequence variation in the EnhII/BCP regions of HBV, and persistence of at-risk sequence variants is critical for HCC development. | - |
dc.relation.ispartof | Gut | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adult; article; blood sampling; cancer diagnosis; cancer patient; case control study; comparative study; confidence interval; control group; controlled study; disease duration; DNA sequence; follow up; genotype; helper virus; hepatitis B; Hepatitis B virus; human; liver cell carcinoma; longitudinal study; major clinical study; male; priority journal; promoter region; risk factor; single nucleotide polymorphism; statistical significance; Adult; Carcinoma, Hepatocellular; Case-Control Studies; Cohort Studies; Enhancer Elements (Genetics); Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Promoter Regions (Genetics); Risk Factors | - |
dc.title | Temporal relationship between hepatitis B virus enhancer II/basal core promoter sequence variation and risk of hepatocellular carcinoma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1136/gut.2006.114066 | - |
dc.identifier.pmid | 17502344 | - |
dc.identifier.scopus | 2-s2.0-38349105023 | - |
dc.relation.pages | 91-97 | - |
dc.relation.journalvolume | 57 | - |
dc.relation.journalissue | 1 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.orcid | 0000-0002-8371-6236 | - |
crisitem.author.orcid | 0000-0002-6202-0993 | - |
crisitem.author.orcid | 0000-0001-8316-3785 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 臨床醫學研究所 |
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