https://scholars.lib.ntu.edu.tw/handle/123456789/568671
標題: | Higher cut-off index value of immunoglobulin M antibody to hepatitis B core antigen in Taiwanese patients with hepatitis B | 作者: | Huang Y.-W. Lin C.-L. PEI-JER CHEN Lai M.-Y. JIA-HORNG KAO DING-SHINN CHEN |
公開日期: | 2006 | 出版社: | Blackwell Publishing | 卷: | 21 | 期: | 5 | 起(迄)頁: | 859-862 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background: The cut-off index value of immunoglobulin M (IgM) antibody to hepatitis B core antigen (anti-HBc; AxSYM CORE-M, Abbott) for diagnosing acute hepatitis B is 1.2. A high false-positive rate of IgM anti-HBc was observed in acute flare-ups of chronic hepatitis B in Taiwanese patients. Thus the purpose of the present paper was to study the optimal index value of IgM anti-HBc in Taiwanese subjects. Methods: The peak index values of 42 IgM anti-HBc-positive patients were collected. There were 20 acute hepatitis B patients and 22 patients with chronic hepatitis B with acute flare. The biochemical, virological, and serological data were obtained. Results: There were significant differences in mean age (36 vs 47 years, P = 0.01), serum alanine aminotransferase level (2042 U/L vs 1193 U/L, P = 0.02) and peak index value of IgM anti-HBc (2.9 vs 1.5, P < 0.01) between patients with acute hepatitis B and those with acute flare of chronic hepatitis B. Eleven (50%) of 22 patients with chronic hepatitis B with acute flare had index value of >1.2. The optimal cut-off index value to differentiate acute hepatitis B from chronic hepatitis B with acute flare was 2.4-2.5, with a sensitivity of 90% and specificity of 90%. Conclusions: The cut-off index value of IgM anti-HBc to differentiate acute hepatitis B from chronic hepatitis B with acute flare among Taiwanese patients should be set at 2.4-2.5 instead of 0.8-1.2. ? 2006 Blackwell Publishing Asia Pty Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984569388&doi=10.1111%2fj.1440-1746.2006.04280.x&partnerID=40&md5=7b8fd81f23fd5fbde1b3cbc1a6ef0b81 https://scholars.lib.ntu.edu.tw/handle/123456789/568671 |
ISSN: | 0815-9319 | DOI: | 10.1111/j.1440-1746.2006.04280.x | SDG/關鍵字: | hepatitis B core antigen; immunoglobulin M antibody; acute hepatitis; adult; aged; antibody detection; antibody titer; article; chronic hepatitis; clinical article; controlled study; diagnostic value; disease activity; disease exacerbation; female; hepatitis B; human; male; priority journal; reference value; serodiagnosis; statistical significance; Taiwan |
顯示於: | 臨床醫學研究所 |
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