https://scholars.lib.ntu.edu.tw/handle/123456789/568759
標題: | Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers | 作者: | JIA-HORNG KAO PEI-JER CHEN Lai M.-Y. DING-SHINN CHEN |
公開日期: | 2003 | 出版社: | W.B. Saunders | 卷: | 124 | 期: | 2 | 起(迄)頁: | 327-334 | 來源出版物: | Gastroenterology | 摘要: | Background & Aims: Hepatitis B viral (HBV) genotype C is associated with the development of hepatocellular carcinoma (HCC) compared with genotype B; however, the virologic factors contributing to the pathogenic differences remain unknown. We investigated the prevalence of T1762/A1764 basal core promoter mutant in a cohort of 250 genotype B- or C-infected HBV carriers with different stages of liver disease to clarify a possible role for this mutant in hepatocarcinogenesis. Methods: The sequences of basal core promoter of HBV genome were determined in 60 inactive HBV carriers and 190 patients with histologically verified chronic liver disease and HCC. Results: Genotype C has a higher prevalence of T1762/A1764 mutation than genotype B (odds ratio, 5.18; 95% confidence interval [CI], 2.59-10.37; P < 0.001). The likelihood of T1762/A1764 mutation parallels the progression of liver disease, from 3% in inactive carriers to 64% in HCC patients (odds ratio, 20.04; 95% CI, 7.25-55.41; P < 0.001). By multiple logistic regression analysis, patients with T1762/A1764 mutation were significantly associated with the development of HCC than those without (odds ratio, 10.60; 95% CI, 4.92-22.86; P < 0.001), and the risk was observed for both genotypes B and C. In addition, the prevalence of T1762/A1764 mutation in younger HCC patients was comparable with older HCC patients but was significantly higher than that in age-matched inactive carriers, irrespective of genotypes. Conclusions: Our data suggest that HBV carriers with T1762/A1764 basal core promoter mutant are at increased risk for HCC and that this mutant may contribute to the pathogenesis of HBV infection. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984549253&doi=10.1053%2fgast.2003.50053&partnerID=40&md5=f4b05f403e481d6451c039d256280497 https://scholars.lib.ntu.edu.tw/handle/123456789/568759 |
ISSN: | 0016-5085 | DOI: | 10.1053/gast.2003.50053 | SDG/關鍵字: | adult; article; cancer risk; chronic liver disease; controlled study; disease carrier; female; gene mutation; gene sequence; genome; genotype; hepatitis B; Hepatitis B virus; human; liver carcinogenesis; liver cell carcinoma; major clinical study; male; mutant; nonhuman; prevalence; priority journal; promoter region |
顯示於: | 臨床醫學研究所 |
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