https://scholars.lib.ntu.edu.tw/handle/123456789/568784
標題: | Increased risk for hepatitis B-related liver cirrhosis in relatives of patients with hepatocellular carcinoma in northern Taiwan | 作者: | MING-WHEI YU Chang H.-C. PEI-JER CHEN CHUN-JEN LIU Liaw Y.-F. Lin S.-M. Lee S.-D. Lin S.-C. Lin C.-L. Chen C.-J. |
公開日期: | 2002 | 出版社: | Oxford University Press | 卷: | 31 | 期: | 5 | 起(迄)頁: | 1008-1015 | 來源出版物: | International Journal of Epidemiology | 摘要: | Background. There is a tendency for familial aggregation of hepatocellular carcinoma (HCC). The aims of this study were to assess the degree to which familial aggregation of hepatitis B surface antigen (HBsAg) carriers accounts for familiality of HCC in families of hepatitis B-related HCC patients, and whether HCC shares a familial predisposition with liver cirrhosis among HBsAg carriers. Methods. A total of 671 first-degree relatives of HBsAg-positive HCC cases were recruited using abdominal ultrasonography and tests for HBsAg and serum aminotransferases. They were from 165 simplex families defined as having only one HCC case and 72 multiplex families with more than one case. In analyses of family history of HCC and cirrhosis, the data set consisted of 4471 unrelated asymptomatic HBsAg carriers recruited in a prospective study. Results. There was no significant difference in the HBsAg-positive rate among relatives between multiplex (55.7%) and simplex (48.1%) families. Sonographic evidence of liver cirrhosis was present in 14.4% of HBsAg-positive relatives from multiplex families but in only 7.8% of HBsAg-positive relatives from simplex families (multiplex versus simplex families: adjusted odds ratio [OR] = 2.29; 95% CI: 1.10-4.77). Among unrelated asymptomatic HBsAg carriers, the adjusted OR of liver cirrhosis associated with a first-degree family history of HCC was 2.80 (95% CI: 1.68-4.66). This association was stronger in HBsAg carriers < 50 years. No association was seen between family history of HCC and hepatitis activity based on elevated levels of aminotransferases. Conclusions. Familial aggregation of HCC in HBsAg carriers is associated with familial clustering of liver cirrhosis. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984535330&doi=10.1093%2fije%2f31.5.1008&partnerID=40&md5=e63dbbb185d659dfbbca3a0db9fe8b3b https://scholars.lib.ntu.edu.tw/handle/123456789/568784 |
ISSN: | 0300-5771 | DOI: | 10.1093/ije/31.5.1008 | SDG/關鍵字: | aminotransferase; hepatitis B surface antigen; cancer; health risk; hepatitis; adult; aminotransferase blood level; article; controlled study; disease association; disease predisposition; familial disease; family history; family study; female; hepatitis B; human; liver cell carcinoma; liver cirrhosis; major clinical study; male; priority journal; prospective study; relative; risk assessment; symptom; Taiwan; ultrasound; virus carrier; Taiwan |
顯示於: | 臨床醫學研究所 |
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