https://scholars.lib.ntu.edu.tw/handle/123456789/568819
標題: | Chromosomal aberrations in nasopharyngeal carcinoma analyzed by comparative genomic hybridization | 作者: | Chen Y.-J. JENG-YUH KO PEI-JER CHEN Shu C.-H. Hsu M.-T. Tsai S.-F. Lin C.-H. |
公開日期: | 1999 | 出版社: | Wiley-Liss Inc. | 卷: | 25 | 期: | 2 | 起(迄)頁: | 169-175 | 來源出版物: | Genes Chromosomes and Cancer | 摘要: | To investigate the genomic imbalances associated with nasopharyngeal carcinoma (NPC), we have performed chromosome analysis by comparative genomic hybridization (CGH) on 51 tumors, including 25 primary and 26 recurrent tumors. The most common copy number increases occurred on chromosome arms 12p (59%), 1q (47%), 17q (47%), 11q (41%), and 12q (35%). The minimal overlapping regions were at 12p12-13, 1q21-22, 17q21, 17q25, 11q13, and 12q13. The most frequent losses were from chromosome arms 3p (53%), 9p (41%), 13q (41%), 14q (35%), and 11q (29%). The minimal overlapping regions were at 3p12-14, 3p25- 26, 9p21-23, 13q21-32, 14q12-21, and 11q14-23. Compared with the primary cancers, no additional chromosomal change was found in the recurrent tumors; however, the most frequent gain in the recurrent NPCs was at 11q13 (53%) instead of 12p in the primary tumors. An increase of gene alterations correlated with clinical stage. Our results provide a first comprehensive view of the genomic changes associated with NPC and reveal several new sites of genomic imbalance, indicating the possible involvement of novel oncogenes/tumor suppressor genes in the carcinogenesis of NPC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984538774&doi=10.1002%2f%28SICI%291098-2264%28199906%2925%3a2%3c169%3a%3aAID-GCC13%3e3.0.CO%3b2-I&partnerID=40&md5=b0a45b606b1f1694f41ebac831187e09 https://scholars.lib.ntu.edu.tw/handle/123456789/568819 |
ISSN: | 1045-2257 | DOI: | 10.1002/(SICI)1098-2264(199906)25:2<169 | SDG/關鍵字: | article; cancer genetics; cancer staging; chromosome aberration; chromosome analysis; chromosome loss; comparative genomic hybridization; correlation function; human; human tissue; nasopharynx carcinoma; priority journal; recurrent cancer; supernumerary chromosome |
顯示於: | 臨床醫學研究所 |
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