https://scholars.lib.ntu.edu.tw/handle/123456789/568832
標題: | Brief communication: Efficacy of ribavirin plus interferon α on viraemia of GB virus-C/hepatitis G virus: Comparison with interferon α alone | 作者: | JIA-HORNG KAO Lai M.-Y. Chen W. PEI-JER CHEN DING-SHINN CHEN |
公開日期: | 1998 | 出版社: | Blackwell Publishing | 卷: | 13 | 期: | 12 | 起(迄)頁: | 1249-1253 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | We investigated the efficacy of ribavirin plus interferon (IFN) α on GB virus-C (GBVC)/hepatitis G virus (HGV) viraemia and compared it with that of interferon α alone in patients coinfected with hepatitis C virus (HCV) and GBV-C/HGV. Serum HCV and GBV-C/HGV-RNA were studied in eight patients with HCV and GBV-C/HGV coinfection, five received IFNα and three received oral ribavirin plus IFNα. Mean serum GBV-C/HGV titre at the end of therapy was significantly lower than the titre just before therapy and patients with lower pretreatment titre had a better sustained response rate. Sustained virological response of GBV-C/HGV to IFNα alone and ribavirin plus IFNα at the end of follow up was observed in one each, respectively. Thus, GBV-C/HGV in patients with HCV and GBV-C/HGV coinfection does respond to IFNα and ribavirin plus IFNα may not induce a higher sustained response. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032254433&doi=10.1046%2fj.1440-1746.1998.01777.x&partnerID=40&md5=2206875d6af4eedc8caef4e3d1b4f410 https://scholars.lib.ntu.edu.tw/handle/123456789/568832 |
ISSN: | 0815-9319 | DOI: | 10.1046/j.1440-1746.1998.01777.x | SDG/關鍵字: | alpha2a interferon; ribavirin; alanine aminotransferase; alpha interferon; ribavirin; virus RNA; adult; article; clinical article; clinical trial; controlled clinical trial; controlled study; dose response; drug efficacy; drug mixture; female; Hepatitis G virus; human; male; oral drug administration; priority journal; randomized controlled trial; relapse; viremia; virus load; blood; comparative study; drug combination; drug effect; Flavivirus; genetics; hepatitis C; middle aged; retrospective study; reverse transcription polymerase chain reaction; treatment outcome; virus hepatitis; Adult; Alanine Transaminase; Drug Therapy, Combination; Female; Flaviviridae; Hepatitis C, Chronic; Hepatitis, Viral, Human; Humans; Interferon-alpha; Male; Middle Aged; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; RNA, Viral; Treatment Outcome; Viremia |
顯示於: | 臨床醫學研究所 |
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