https://scholars.lib.ntu.edu.tw/handle/123456789/568904
Title: | A viral mechanism in acute exacerbations of chronic type B hepatitis: Hepatitis B virus reinfection and subsequent reactivation of two viral strains | Authors: | PEI-JER CHEN Chen M.L. Chen D.S. |
Keywords: | Chronic type B hepatitis; Hepatitis B virus reinfection; Mixed viral strains in acute exacerbations | Issue Date: | 1993 | Publisher: | Kluwer Academic Publishers | Journal Volume: | 1 | Journal Issue: | 1 | Start page/Pages: | 7-12 | Source: | Journal of Biomedical Science | Abstract: | Chronic hepatitis B virus (HBV) infections are frequently associated with exacerbations of hepatitis of which the majority are due to reactivation of viral activity. Variation in a viral genome during persistent infection has been shown to be a possible cause for reactivation. In this study, we have found another possible mechanism. HBV in a patient with repeated exacerbations was isolated at six different times during follow-up and was characterized by polymerase chain reaction and DNA sequencing. The first episode of exacerbation was accompanied with increased replication of an HBV strain. The second episode, however, was associated with the sudden appearance of an HBV strain that displayed enough sequence variations to warrant the designation as a separate strain. The results suggested a reinfection event by another independent HBV. Subsequent exacerbations were then related to coactivation of both viral stains. These observations provide significant information toward understanding the acute exacerbations of chronic type B hepatitis. ? 1994 National Science Council. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984538400&doi=10.1007%2fBF02258334&partnerID=40&md5=77818e892143b8d707f15e3d0c009c59 https://scholars.lib.ntu.edu.tw/handle/123456789/568904 |
ISSN: | 1021-7770 | DOI: | 10.1007/BF02258334 |
Appears in Collections: | 臨床醫學研究所 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.