https://scholars.lib.ntu.edu.tw/handle/123456789/568957| Title: | Cost minimization comparison of oral UFT/leucovorin versus 5-fluorouracil/leucovorin as adjuvant therapy for colorectal cancer in Taiwan | Authors: | Hsu T.-C. CHI-CHUAN WANG |
Keywords: | chemotherapy; cost-effective; NHI reimbursement price; oral; stage II and III colorectal cancer; UFT; uracil-tegafur | Issue Date: | 2019 | Journal Volume: | 8 | Journal Issue: | 2 | Start page/Pages: | 73-79 | Source: | Journal of Comparative Effectiveness Research | Abstract: | Aim: Oral uracil-tegafur/leucovorin (UFT/LV) and intravenous 5-fluorouracil (FU)/LV are common adjuvant therapies for Stages II and III colorectal cancer. This study aims to determine the most cost-effective treatment alternative between UFT/LV and 5-FU/LV in Stages II and III colorectal cancer from Taiwan's National Health Insurance perspective. Patients & methods: The costs were referenced directly from the National Health Insurance reimbursement price. Chemotherapy regimen considered for the cost analysis calculation was adapted from NSABP-C-06 study, and, a time saving calculation was also included. In addition, we compare the treatment outcome. Result: A total cost saving of US$3620.80-$3709.16 per patient per treatment was achieved with the UFT/LV treatment. UFT/LV provides the comparable outcome to 5-FU/LV. Conclusion: UFT/LV was the more cost-effective treatment as adjuvant chemotherapy. ? 2019 2018 Future Medicine Ltd. |
URI: | 2-s2.0-85059096340 https://scholars.lib.ntu.edu.tw/handle/123456789/568957 |
ISSN: | 20426305 | DOI: | 10.2217/cer-2018-0078 | metadata.dc.subject.other: | fluorouracil; folinic acid; UFT; ufur; antineoplastic agent; antineoplastic antimetabolite; fluorouracil; folinic acid; tegafur; uracil; vitamin B complex; Article; cancer chemotherapy; cancer staging; clinical article; colorectal cancer; controlled study; cost benefit analysis; cost control; cost effectiveness analysis; disease free survival; drug cost; hospital admission; human; multiple cycle treatment; overall survival; priority journal; Taiwan; treatment outcome; adjuvant chemotherapy; adult; aged; colorectal tumor; economics; female; health care cost; male; middle aged; multimodality cancer therapy; oral drug administration; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Cost Control; Female; Fluorouracil; Health Care Costs; Humans; Leucovorin; Male; Middle Aged; Taiwan; Tegafur; Treatment Outcome; Uracil; Vitamin B Complex [SDGs]SDG3 |
| Appears in Collections: | 藥學系 |
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