https://scholars.lib.ntu.edu.tw/handle/123456789/569172
標題: | Insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor formation and invasion and predicts poor prognosis in oral squamous cell carcinoma | 作者: | Lin C.-Y. Chen S.-T. YUNG-MING JENG Yeh C.-C. HAN-YI E. CHOU YI-TING DENG Chang C.-C. YEN-PING KUO |
公開日期: | 2011 | 卷: | 40 | 期: | 9 | 起(迄)頁: | 699-705 | 來源出版物: | Journal of Oral Pathology and Medicine | 摘要: | Insulin-like growth factor II mRNA-binding protein 3 (IGF2BP3), an oncofetal RNA-binding protein, has been implicated in the enhancement of proliferation and invasion in various cancers. This study aimed to investigate the clinical significance and functional role of IGF2BP3 expression in oral squamous cell carcinoma (OSCC). Methods: IGF2BP3 expression in 93 OSCC patients was investigated using immunohistochemical staining and correlated with clinical parameters and patients' survival. The effect of IGF2BP3 on cell invasion ability was evaluated by RNA interference in OSCC cell line. Results: High expression of IGF2BP3 in OSCC was significantly correlated with large tumor size and lymph node metastasis. Kaplan-Meier analysis revealed that oral cancer patients with high IGF2BP3 expression had a significantly lower 5-year survival (P=0.0017). Multivariate analysis of clinical samples demonstrated IGF2BP3 to be an independent prognosis factor (P=0.003). Moreover, the IGF2BP3 shRNA significantly suppressed the invasion ability of OSCC in vitro, and the knockdown of endogenous IGF2BP3 expression also inhibited tumor formation in vivo. Conclusions: IGF2BP3 enhances cell invasion ability and tumorigenicity in human OSCC in vitro and in vivo. IGF2BP3 is an independent prognostic factor in patients with OSCC. Targeting of IGF2BP3 could potentially suppress the tumor growth and metastasis to improve the outcome of patients with OSCC. ? 2011 John Wiley & Sons A/S. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80053576400&doi=10.1111%2fj.1600-0714.2011.01019.x&partnerID=40&md5=7b08c47457fc1b9f433bcdd9379e98a5 https://scholars.lib.ntu.edu.tw/handle/123456789/569172 |
ISSN: | 0904-2512 | DOI: | 10.1111/j.1600-0714.2011.01019.x | SDG/關鍵字: | insulin like growth factor II mRNA binding protein 3; messenger RNA; short hairpin RNA; somatomedin B; somatomedin binding protein 3; unclassified drug; animal cell; article; cancer diagnosis; cancer patient; cancer survival; carcinogenesis; clinical feature; controlled study; female; human; human cell; immunohistochemistry; in vivo study; lymph node metastasis; major clinical study; male; mouse; mouth carcinoma; nonhuman; oral squamous cell carcinoma; priority journal; protein binding; protein expression; protein function; RNA interference; squamous cell carcinoma; survival time; tumor growth; tumor volume; Aged; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Mouth Neoplasms; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; RNA Interference; RNA, Messenger; RNA, Small Interfering; RNA-Binding Proteins; Survival Rate; Tumor Markers, Biological |
顯示於: | 牙醫學系 |
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