https://scholars.lib.ntu.edu.tw/handle/123456789/569202
標題: | Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quid chewing | 作者: | JANG-JAER LEE YEN-PING KUO SHIH-JUNG CHENG CHUN-PIN CHIANG JIIANG-HUEI JENG HAO-HUENG CHANG Kuo Y.-S. Lan W.-H. SANG-HENG KOK |
公開日期: | 2005 | 出版社: | Mosby Inc. | 卷: | 99 | 期: | 4 | 起(迄)頁: | 471-478 | 來源出版物: | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology | 摘要: | Objective. The aim of the study was to examine the expressions of p53 and proliferating cell nuclear antigen (PCNA) in oral lichen planus (OLP) in relation to its clinical behavior and the patients' oral habits. Study design. Immunohistochemical study was carried out to investigate the expressions of p53 and PCNA in 56 OLP specimens. The results were correlated with the clinical behavior of the disease and the patients' oral habits. The expression rates were further compared with those of normal oral mucosa (NOM), epithelial hyperkeratosis (EH), epithelial dysplasia (ED), and squamous cell carcinoma (SCC). Results. The staining rate of p53 (28.6%) and PCNA labeling index (LI) (27.6 ± 8.8%) in OLP were similar to those in EH (P = .868, .074, respectively), but higher than those of NOM and lower than those of ED and SCC (all P < .05). In OLP, no significant correlations were found between p53 or PCNA expression and the patients' age, gender, lesion duration, location, size, number of site, presence of pain, presence of local irritant, and the habits of alcohol drinking and cigarette smoking (all P > .05). In addition, the mean PCNA LI of p53+ cases was close to that of p53- cases (P = .38). However, the staining rate of p53 in OLP was higher in areca quid (AQ) chewers compared to abstainers (P = .001), and the mean PCNA LI in atrophic cases was higher than that in hypertrophic cases (P = .029). Interestingly, the staining rate of p53 and mean PCNA LI were significantly increased in AQ chewers with atrophic OLP (100%, 36.7% ± 9.0%, respectively), which were similar to those in ED and SCC (all P > .05). Conclusions. Although this study could not confirm the precancerous nature of OLP by the relatively low p53 and PCNA expression, the results do suggest that atrophic form OLP and patients with AQ chewing habit may have a higher disease activity in view of higher expression rates of p53 and PCNA in the lesions. ? 2005 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-15044340894&doi=10.1016%2fj.tripleo.2004.10.018&partnerID=40&md5=936e4a862db33bc0eae8abec154a3b37 https://scholars.lib.ntu.edu.tw/handle/123456789/569202 |
ISSN: | 1079-2104 | DOI: | 10.1016/j.tripleo.2004.10.018 | SDG/關鍵字: | cycline; protein p53; adolescent; adult; age distribution; aged; article; betel nut; cell proliferation; cigarette smoking; controlled study; correlation analysis; drinking behavior; female; human; human cell; human tissue; hyperkeratosis; hypertrophy; immunohistochemistry; lichen planus; major clinical study; male; pain assessment; protein expression; sex ratio; squamous cell carcinoma |
顯示於: | 牙醫學系 |
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