https://scholars.lib.ntu.edu.tw/handle/123456789/569608
Title: | Combination of LED light and platelet-derived growth factor to accelerate dentoalveolar osteogenesis | Authors: | PO-CHUN CHANG CHEN-YING WANG Sheng-Chueh T. |
Issue Date: | 2014 | Publisher: | Blackwell Munksgaard | Journal Volume: | 41 | Journal Issue: | 10 | Start page/Pages: | 999-1006 | Source: | Journal of Clinical Periodontology | Abstract: | Aim This study aimed to evaluate the adjunctive effect of LED light in platelet-derived growth factor (PDGF)-aided dentoalveolar osteogenesis. Material and Methods Full-thickness osseous wounds were created on rat maxillae and were either unfilled or filled with poly-(D,L-lactide) and poly-(D,L-lactide-co-glycolide) microspheres encapsulating PDGF. Animals received daily 660 ± 25 nm LED light irradiation at 0, 10 (LD), or 20 (HD) J/cm2, were killed at days 4-28 (n = 6/group/time) and evaluated by microcomputed tomography (micro-CT), histology, and the expressions of osteopontin and tartrate-resistant acid phosphatase (TRAP). Results Greater osteogenesis was noted in the PDGF-treated defects at day 14. Under the LED light irradiation, osteogenesis was significantly greater in both LD and HD groups of the non-PDGF-treated defects, but only in the LD group of the PDGF-treated defects. No significant differences in osteogenesis among groups were noted at day 28. Greater bone marrow space was noted in the LED light-irradiated specimens, especially in the PDGF-treated defects at both time points. Osteopontin was significantly promoted in the LD group at both time points, and TRAP was significantly promoted in all LED light-irradiated groups at day 28. Conclusion LED light could an adjunct to promote early PDGF-aided dentoalveolar osteogenesis by facilitating the osteoblast-osteoclast coupling. ? 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937638402&doi=10.1111%2fjcpe.12301&partnerID=40&md5=3aafb96f6dd9f474d82cc8d83b476705 https://scholars.lib.ntu.edu.tw/handle/123456789/569608 |
ISSN: | 0303-6979 | DOI: | 10.1111/jcpe.12301 | SDG/Keyword: | acid phosphatase; biomaterial; drug carrier; isoenzyme; lactic acid; microsphere; osteopontin; platelet derived growth factor B; platelet-derived growth factor BB; polyester; polyglycolic acid; polylactic acid-polyglycolic acid copolymer; polylactide; Spp1 protein, rat; tartrate-resistant acid phosphatase; animal; bone density; bone development; bone marrow; chemistry; comparative study; drug effects; low level laser therapy; male; Maxillary Diseases; micro-computed tomography; multimodality cancer therapy; osteoblast; osteoclast; pathology; physiology; procedures; radiation response; randomization; rat; Sprague Dawley rat; time; tooth socket; Acid Phosphatase; Animals; Biocompatible Materials; Bone Density; Bone Marrow; Combined Modality Therapy; Drug Carriers; Isoenzymes; Lactic Acid; Laser Therapy, Low-Level; Male; Maxillary Diseases; Microspheres; Osteoblasts; Osteoclasts; Osteogenesis; Osteopontin; Polyesters; Polyglycolic Acid; Proto-Oncogene Proteins c-sis; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors; Tooth Socket; X-Ray Microtomography |
Appears in Collections: | 臨床牙醫學研究所 |
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