https://scholars.lib.ntu.edu.tw/handle/123456789/570268
標題: | Significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high homocysteine level with recurrent aphthous stomatitis | 作者: | Sun A. HSIN-MING CHEN SHIH-JUNG CHENG YI-PING WANG JULIA YU-FONG CHANG Wu Y.-C. CHUN-PIN CHIANG |
公開日期: | 2015 | 出版社: | Blackwell Publishing Ltd | 卷: | 44 | 期: | 4 | 起(迄)頁: | 300-305 | 來源出版物: | Journal of Oral Pathology and Medicine | 摘要: | Background: A portion of patients with recurrent aphthous stomatitis (RAS) may have nutritional deficiency. This study evaluated whether there was an intimate association of the deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high blood homocysteine level with RAS. Methods: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations in 273 RAS patients were measured and compared with the corresponding levels in 273 age- and sex-matched healthy control subjects. Results: We found that 57 (20.9%), 55 (20.1%), 13 (4.8%), and 7 (2.6%) RAS patients had deficiencies of hemoglobin (Men < 13 g/dl, Women < 12 g/dl), iron (<60 μg/dl), vitamin B12 (<200 pg/ml), and folic acid (<4 ng/ml), respectively. Moreover, 21 (7.7%) RAS patients had abnormally high blood homocysteine level. RAS patients had a significantly higher frequency of hemoglobin, iron, vitamin B12, or folic acid deficiency and of abnormally elevated blood homocysteine level than healthy control subjects (all P-values = 0.000 except for folic acid P = 0.022). If 273 RAS patients were further divided into 32 patients with major-typed RAS (MjRAS) and 241 patients with minor-typed RAS (MiRAS), we found that male MjRAS patients had a significantly lower mean hemoglobin concentration than MiRAS patients (P = 0.021), but MjRAS patients had a significantly higher mean homocysteine level than MiRAS patients (P = 0.000). Conclusion: We conclude that there is a significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and abnormally high blood homocysteine level with RAS. ? 2014 John Wiley & Sons A/S. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926156772&doi=10.1111%2fjop.12241&partnerID=40&md5=80172ab45878d6b83003029dea8bbc76 https://scholars.lib.ntu.edu.tw/handle/123456789/570268 |
ISSN: | 0904-2512 | DOI: | 10.1111/jop.12241 | SDG/關鍵字: | cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; hemoglobin; homocysteine; adult; aged; aphthous stomatitis; Article; clinical assessment; controlled study; correlation analysis; female; folic acid blood level; hemoglobin blood level; human; iron blood level; major clinical study; male; nutritional deficiency; priority journal; statistical analysis; vitamin blood level; adolescent; aphthous stomatitis; blood; chi square distribution; cyanocobalamin deficiency; deficiency; folic acid deficiency; iron deficiency anemia; middle aged; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Anemia, Iron-Deficiency; Chi-Square Distribution; Female; Folic Acid Deficiency; Hemoglobins; Homocysteine; Humans; Male; Middle Aged; Stomatitis, Aphthous; Vitamin B 12 Deficiency; Young Adult |
顯示於: | 臨床牙醫學研究所 |
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