https://scholars.lib.ntu.edu.tw/handle/123456789/570294
標題: | Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis | 作者: | ANDY SUN Lin H.-P. YI-PING WANG CHUN-PIN CHIANG |
關鍵字: | Atrophic glossitis; Gastric parietal cell antibody; Hemoglobin; Homocysteine; Iron; Vitamin B12 | 公開日期: | 2012 | 卷: | 41 | 期: | 6 | 起(迄)頁: | 500-504 | 來源出版物: | Journal of Oral Pathology and Medicine | 摘要: | Background: Atrophic glossitis (AG) is considered to be a marker of nutritional deficiency. In this study, we evaluated whether there was an intimate association of the deficiency of hemoglobin, iron, vitamin B12 or folic acid, high blood homocysteine level, and serum gastric parietal cell antibody (GPCA) positivity with AG. Methods: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations and the serum GPCA level in 176 AG patients were measured and compared with the corresponding levels in 176 age- and sex-matched healthy control subjects. Results: We found that 39 (22.2%), 47 (26.7%), 13 (7.4%), and 3 (1.7%) AG patients had deficiencies of Hb (men<13g/dl, women<12g/dl), iron (<60μg/dl), vitamin B12 (<200pg/ml), and folic acid (<4ng/ml), respectively. Moreover, 38 (21.6%) AG patients had abnormally high blood homocysteine level, and 47 (26.7%) AG patients had serum GPCA positivity. AG patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, or of serum GPCA positivity than healthy control subjects (all P-values=0.000). However, no significant difference in frequency of folic acid deficiency was found between AG patients and healthy control subjects. Conclusion: We conclude that there is a significant association of deficiency of hemoglobin, iron and vitamin B12, abnormally high blood homocysteine level, and serum GPCA positivity with AG. ? 2011 John Wiley & Sons A/S. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84858406745&doi=10.1111%2fj.1600-0714.2011.01122.x&partnerID=40&md5=1e3ce2794574340ac97ab8ba24f30ec0 https://scholars.lib.ntu.edu.tw/handle/123456789/570294 |
ISSN: | 0904-2512 | DOI: | 10.1111/j.1600-0714.2011.01122.x | SDG/關鍵字: | cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; parietal cell antibody; adult; aged; article; atrophic glossitis; blood level; burning sensation; Candida albicans; concentration (parameters); controlled study; female; glossitis; human; major clinical study; male; paresthesia; priority journal; stomach parietal cell; thrush; varicosis; xerostomia; Adult; Aged; Aged, 80 and over; Antibodies; Atrophy; Burning Mouth Syndrome; Candidiasis, Oral; Case-Control Studies; Female; Folic Acid Deficiency; Glossitis; Hemoglobins; Humans; Hyperhomocysteinemia; Hypesthesia; Iron; Male; Middle Aged; Parietal Cells, Gastric; Taste Disorders; Tongue; Tongue Diseases; Varicose Veins; Vitamin B 12 Deficiency; Xerostomia |
顯示於: | 臨床牙醫學研究所 |
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